Private channel session 872

8 messages over 1h 20m, 2021-01-25 – 2021-01-25.

A “conversation” here is an activity session — a run of messages with under 60 minutes of silence inside it. The channel had no native conversation boundaries.

1. 2021-01-25 11:46 Robert F. Garry open PDF p.449
   Cambobatcov spike pretty interesting - it has the E484 and 5/6 of the GD Pango/SC2 RBD residues we highlighted in PO1. Add to that the furin landing site QTQTN that it shares with PangoGD CoV and RatG13. [shared file(s): image.png]
2. 2021-01-25 11:55 Robert F. Garry open PDF p.449
   So bottom line a new bat virus that confirms the authenticity of GD pangocov.
3. 2021-01-25 12:09 Edward C. Holmes open PDF p.449
   Brilliant work Bob! The Cambobatcov paper should be online soon I believe
4. 2021-01-25 12:14 Robert F. Garry open PDF p.449
   That would be great - have some ideas gelling for an "opinion" piece for Virological. Something along the lines of:New sequences disprove conspiracy theories based on contrived origins of bat coronavirus RatG13 and pangolin coronaviruses.
5. 2021-01-25 12:44 Edward C. Holmes open PDF p.449
   Love it! Looking forward to having a rant on Twitter
6. 2021-01-25 12:59 Andrew Rambaut open PDF p.450
   Amazing. So the Cambobat has the RBD that RaTG13 lost through recombination and is slightly closer than the GD pango by the looks?
7. 2021-01-25 13:01 Andrew Rambaut open PDF p.450
   On closer inspection maybe it isn't quite that simple but hey - really interesting
8. 2021-01-25 13:06 Robert F. Garry open PDF p.450
   Yes, but I think your first approximation is pretty spot on - taking a look at the nucleotide alignment - maybe a case where the protein alignment gives a slightly different picture than the nucleotide alignment. - as ProfBill often saysyou can see the "wobble" codons. That's natural evolution of course not nonsense like the WIV supervillains creatinga fake set of SRA data to cover up their GOF/bioweapons program.