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Slack / Private Message Drop, p.423 [SLACK_000637] · slack_pm:msg:04372

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I'm not sure I've seen the vero cell sequences either. I'll ask Tommy what his plans for it are.

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2021-01-19 03:30 Robert F. Garry open

The post about the PangoGD HV indel is VERY interesting [smart guy that Tommy] - not sure whether the vero cell passage sequence was posted or not [????}. This is VERY similar to SC2 backfilling indel region 4 after Vero possage (Karthik et al). There are different "evolutionary/selective" pressures in these indels when you take them out of humans/animals and put them in cell culture. Tommy should make his post ASAP - it's quite important andanticipate/backs up what we're saying. Meanwhile @Andrew Rambaut there's a bit in the Ruff draft that's almost done regarding our friend Yuri of blast alignment fame - can you check for appropriateness?
2021-01-19 03:32 Robert F. Garry open

Yes indeed the stench of BS from the GSAID guy is vomit-inducing.
2021-01-19 03:36 Edward C. Holmes

I'm not sure I've seen the vero cell sequences either. I'll ask Tommy what his plans for it are.
2021-01-19 03:41 Andrew Rambaut open

@Robert Garry I will take a look at the ruff today.
2021-01-19 03:54 Robert F. Garry open

@Robert Garry Great thanks! - few housekeeping tasks with seq Ids and refs but otherwise pretty clean.
2021-01-19 04:43 Robert F. Garry open

The Vero cell pango is indeed posted - interesting it backfills BOTH indel 3 and 6! [shared file(s): image.png]
2021-01-19 04:44 Andrew Rambaut open

What is the nucleotide sequence? Is there a repeat? Could it be a slippage (forwards for deletion, backwards to insert).