Slack / Private Message Drop — page 402

Me to! Umlaut, also known as diaeresis, i-umlaut or - wait for it - i-mutation, is a mark that consists of two dots ( ̈) placed over a letter, usually a vowel, to indicate a different quality. Only one word I believe in Webster's American English [I know other English out there] that still allows the use of the mark as a variant: *naïveté.* Ironically, the root *naïve* is a French adjective meaning "natural, just born" just like SARS-CoV-2. [2021-01-15 06:40:52] [Robert Garry] Use *naïveté* in a sentence: It is the height of *naïveté* to claim that one can infer the evolutionary origins of the RmYN02 S1/S2 cleavage site by performing a simple nucleotide alignment as advanced by some proponents of the lab origin hypothesis [1]. 1. The genetic structure of SARSnCoVn2 does not rule out a laboratory origin SARSnCOVn2 chimeric structure and furin cleavage site might be the result of genetic manipulation Rossana Segreto Yuri Deigin [2021-01-15 10:14:02] [Kristian Andersen] @Andrew Rambaut - do you guys have any concerns about L452R? [2021-01-15 10:30:19] [Andrew Rambaut] I wasn't until you just asked me. [2021-01-15 10:51:43] [Kristian Andersen] Oh boy. What did I do - anything in your data? We saw it yesterday here in San Diego, but Charles Chiu just told me it's at 25% in LA [2021-01-15 10:56:06] [Kristian Andersen] What the hell is going on with this binding affinity thingamajig. https://arxiv.org/pdf/2005.14669.pdf [2021-01-15 11:10:02] [Andrew Rambaut] 86 with L452R in England. [2021-01-15 11:11:14] [Kristian Andersen] Recent and on B.1.1.7 background? [2021-01-15 11:11:27] [Kristian Andersen] (and I said LA - it's actually Northern California) [2021-01-15 11:12:10] [Andrew Rambaut] A few from lineage A with N501Y too: Denmark/DCGC-22492/2020,2020-12-14,A,synSNP:A361G|orf1ab:P286L|synSNP:C2509T|synSNP:C8782T|orf1a b:D2980G|orf1ab:N3651S|synSNP:A11326G|synSNP:C16293T|orf1ab:P5401L|synSNP:A18366G|synSNP:A20262 G|S:L18F|synSNP:G22468T|S:L452R|S:*N501Y*|S:A653V|S:H655Y|S:D796Y|S:G1219V|ORF3a:V50A|synSNP:C2 7247T|ORF8:L84S|N:S202N|synSNP:T29344A|N:D358N England/PHEC-150B87/2020,2020-12-23,A,synSNP:A361G|orf1ab:P286L|synSNP:C2509T|synSNP:C8782T|orf1a b:D2980G|orf1ab:N3651S|orf1ab:T4265I|orf1ab:Q4392H|synSNP:C16293T|orf1ab:P5401L|synSNP:A18366G|orf1a b:L6082F|orf1ab:A6544V|synSNP:A20262G|S:L18F|synSNP:C21658T|synSNP:G22468T|S:L452R|S:*N501Y*|S:A6 53V|S:H655Y|S:D796Y|S:G1219V|ORF3a:V50A|synSNP:A26154G|synSNP:C27247T|ORF8:L84S|N:S202N England/PHEC-150B96/2020,2020-12-23,A,synSNP:A361G|orf1ab:P286L|synSNP:C2509T|synSNP:C8782T|orf1a b:D2980G|orf1ab:N3651S|orf1ab:Q4392H|synSNP:C16293T|orf1ab:P5401L|orf1ab:K5542R|synSNP:A18366G|orf1 ab:L6082F|orf1ab:A6544V|synSNP:A20262G|S:L18F|synSNP:C21658T|synSNP:G22468T|S:L452R|S:*N501Y*|S:A 653V|S:H655Y|S:D796Y|S:G1219V|ORF3a:V50A|synSNP:A26154G|synSNP:C27247T|ORF8:L84S|N:S202N