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Slack / Private Message Drop, p.385 [SLACK_000599] · slack_pm:msg:04012

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Also, "immunocompromised" covers a huge range of contexts...

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2021-01-11 16:01 Edward C. Holmes open

I don't think we have any info from previous immunocompromised cases (noros, flu) for such large-scale convergent evolution. Indeed, while I can see immunocompromised cases leading to lots of mutations, lots of the SAME mutations appearing multiple times does smell of very strong and directed selection.
2021-01-11 16:09 Andrew Rambaut open

Just don't know - so much other stuff presumably hitchiking - I just don't think that likely happens via a progressionof individual mutations with bottlenecking transmission.
2021-01-11 16:11 Andrew Rambaut open

We are seeing all these mutations cropping up individually many times. But when they appear in combination now we also get 15 other mutations along side
2021-01-11 16:14 Edward C. Holmes open

I assume there's no recombination involved?
2021-01-11 16:17 Edward C. Holmes

Also, "immunocompromised" covers a huge range of contexts...
2021-01-11 16:18 Andrew Rambaut open

Can't see anything obvious (recombination)
2021-01-11 16:18 Andrew Rambaut open

But need to keep an eye on that.
2021-01-11 16:19 Andrew Rambaut open

I have been careful not to say immunocompromised - only chronically infected
2021-01-11 16:19 Robert F. Garry open

The NSP6 deletion is downstream of a crazy T rich region.