Slack / Private Message Drop — page 385

[2021-01-11 15:52:07] [Kristian Andersen] Maybe together with Doug and Nelly they're up to no good. [2021-01-11 15:52:28] [Robert Garry] I think Doug did it...or at least maybe started the process -that is of course after the FCS inserted itself. [2021-01-11 15:52:57] [Kristian Andersen] Let's call that initial event Furio [2021-01-11 15:53:32] [Kristian Andersen] Furio > Hugo > Doug > Nelly > Eeek, Pooh. I see a pattern emerging. [2021-01-11 15:59:46] [Robert Garry] Yeah - it's all going to shit... [2021-01-11 16:01:36] [Eddie Holmes] I don't think we have any info from previous immunocompromised cases (noros, flu) for such large-scale convergent evolution. Indeed, while I can see immunocompromised cases leading to lots of mutations, lots of the SAME mutations appearing multiple times does smell of very strong and directed selection. [2021-01-11 16:09:50] [Andrew Rambaut] Just don't know - so much other stuff presumably hitchiking - I just don't think that likely happens via a progression of individual mutations with bottlenecking transmission. [2021-01-11 16:11:21] [Andrew Rambaut] We are seeing all these mutations cropping up individually many times. But when they appear in combination now we also get 15 other mutations along side [2021-01-11 16:14:59] [Eddie Holmes] I assume there's no recombination involved? [2021-01-11 16:17:47] [Eddie Holmes] Also, "immunocompromised" covers a huge range of contexts... [2021-01-11 16:18:37] [Andrew Rambaut] Can't see anything obvious (recombination) [2021-01-11 16:18:50] [Andrew Rambaut] But need to keep an eye on that. [2021-01-11 16:19:22] [Andrew Rambaut] I have been careful not to say immunocompromised - only chronically infected