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Slack / Private Message Drop, p.345 [SLACK_000559] · slack_pm:msg:03628

Date: 2020-12-28 14:46
Type: chat message · slack
recipient: Kristian G. Andersen, Robert F. Garry, Andrew Rambaut
speaker: Edward C. Holmes

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Bob - I was also involved in a cat study: [shared file(s): A household case evidences shorter shedding of SARS CoV2 in naturally infected cats compared to their human owners.pdf]

In context

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2020-12-28 14:05 Robert F. Garry open

Continuing my learning exercise for today. https://academic.oup.com/cid/article/71/9/2428/5811871 Infection of hamsters occurs effectively, and there are moderate symptoms. I haven't found much sequence data except Spike in this paper. There was only one mutation in one "serial" [contact] animal. S H655Y just like in the serial cats in the previous example, which is probably not a coincidence. Hamsters have Q34 instead of H34, but have Y41/K353 like humans.
2020-12-28 14:41 Robert F. Garry open

Tiger: https://mra.asm.org/content/9/22/e00468-20 Identical in S to Wu-1 except D614G.
2020-12-28 14:41 Edward C. Holmes open

Tigers keep getting infected. Very interesting.
2020-12-28 14:44 Edward C. Holmes open

And here is a new data point for your consumption only - that Cambodian bat virus that mentioned in that Nature news piece without any info...closer than I expected: [shared file(s): data_fullgenome_aligned.fas.tree.pdf]
2020-12-28 14:46 Edward C. Holmes

Bob - I was also involved in a cat study: [shared file(s): A household case evidences shorter shedding of SARS CoV2 in naturally infected cats compared to their human owners.pdf]
2020-12-28 14:46 Robert F. Garry open

Indeed - several zoos and various cats including leopards and lions.
2020-12-28 14:50 Edward C. Holmes open

I don't have the sequence for that Cambodian virus and I'll see I can get hold of the key bits of the spike protein. Iwas told it was 'quite divergent'.
2020-12-28 14:50 Robert F. Garry open

@Eddie Holmes Oh that's very interesting! Will be interested to see Spike.
2020-12-28 14:53 Edward C. Holmes open

@Eddie Holmes I'll see what I can do...complex politics.

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