A single line often inverts meaning once you see what it
answers, so neighbouring messages are always shown.
-
FWIW - the same story in dogs https://www.nature.com/articles/s41586-020-2334-5 [not sure how I missed this one]. Both the cat and dog S sequences are 99% similar to Wu-1 S. The dog seq is identical except for D614G.
-
https://www.biorxiv.org/content/10.1101/2020.11.16.384917v1.full.pdf A little more about cats. Serial passage does select for a few variants: The ones that get fixed are S H655Y andE S67S. According to the authors: "S H655Y isnear the polybasic cleavage site, residin between the receptor binding domain and the fusion peptide, and is thoughtto modulate Spike glycoprotein fusion efficiency 55,56,59 262 . E S67S has not been documented elsewhere." It's not that near the FCS, but I take the point...
-
Continuing my learning exercise for today. https://academic.oup.com/cid/article/71/9/2428/5811871 Infection of hamsters occurs effectively, and there are moderate symptoms. I haven't found much sequence data except Spike in this paper. There was only one mutation in one "serial" [contact] animal. S H655Y just like in the serial cats in the previous example, which is probably not a coincidence. Hamsters have Q34 instead of H34, but have Y41/K353 like humans.
-
Tiger: https://mra.asm.org/content/9/22/e00468-20 Identical in S to Wu-1 except D614G.
-
2020-12-28 14:41
Edward C. Holmes
Tigers keep getting infected. Very interesting.
-
And here is a new data point for your consumption only - that Cambodian bat virus that mentioned in that Nature news piece without any info...closer than I expected: [shared file(s): data_fullgenome_aligned.fas.tree.pdf]
-
Bob - I was also involved in a cat study: [shared file(s): A household case evidences shorter shedding of SARS CoV2 in naturally infected cats compared to their human owners.pdf]
-
Indeed - several zoos and various cats including leopards and lions.
-
I don't have the sequence for that Cambodian virus and I'll see I can get hold of the key bits of the spike protein. Iwas told it was 'quite divergent'.