Chat message

Slack / Private Message Drop, p.335 [SLACK_000549] · slack_pm:msg:03529

Date: 2020-12-21 14:30
Type: chat message · slack
recipient: Kristian G. Andersen, Robert F. Garry, Edward C. Holmes
speaker: Andrew Rambaut

Recipients on this medium are inferred from channel membership, not per-message addressing.

Here are all the mutations from Wuhan: Spike D614G, Spike N501Y, N G204R, N Q9H, N R203K, NS3 Y156C, NS7a T14I, NSP3 H1539Y, NSP3 S126L, NSP5 G71S, NSP5 P132L, NSP12 P323L, NSP15 A217V, NSP15 M271I, NSP15 T33I

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2020-12-21 14:26 Andrew Rambaut open

You mean what muts it has?
2020-12-21 14:27 Kristian G. Andersen open

A GISAID ID? Creating an alignment for Andrew Ward so he can get a cryo guy on it and he wanted a prioritized listof sequences
2020-12-21 14:29 Robert F. Garry open

https://www.propublica.org/article/here-are-six-accidents-unc-researchers-had-with-lab-created-coronaviruses"*April2020*: A UNC scientist underwent 14 days of self-quarantine at home after a mouse bite caused potential exposureto a strain of SARS-CoV-2, the virus that causes COVID-19, that had been adapted for growth in mice. The incidentin a biosafety level 3 lab happened when a researcher attempted to read the ID number on a tag on a mouse's ear.The mouse flipped over in the researcher's hand and bit an index finger through two layers of gloves. It did not appear to break the researcher's skin, but UNC told NIH in its reports that "given the uncertainty surrounding the exposure, we are treating this as a medium/high risk exposure." The researcher was instructed to self-quarantine and do twice-daily temperature checks. UNC also notified the local Health Department. No further information about the worker's health was included in the incident reports."
2020-12-21 14:30 Andrew Rambaut open

Very confusingly (and coincidentally) it is lineage B.1.1.70
2020-12-21 14:30 Andrew Rambaut

Here are all the mutations from Wuhan: Spike D614G, Spike N501Y, N G204R, N Q9H, N R203K, NS3 Y156C, NS7a T14I, NSP3 H1539Y, NSP3 S126L, NSP5 G71S, NSP5 P132L, NSP12 P323L, NSP15 A217V, NSP15 M271I, NSP15 T33I
2020-12-21 14:30 Andrew Rambaut open

EPI_ISL_710967
2020-12-21 14:30 Kristian G. Andersen open

Awesome - thanks
2020-12-21 14:31 Andrew Rambaut open

(most 501Y from Wales are this lineage at the moment but it is changing)
2020-12-21 14:31 Andrew Rambaut open

So no other spikes apart from 614G but everyone has one of those these days

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