Slack / Private Message Drop — page 335

[2020-12-21 14:13:22] [Kristian Andersen] That E484K gotta be making some major differences in the structure [2020-12-21 14:19:34] [Robert Garry] Going full in: the FCS of some strains of mouse hepatitis virus is *H*RARRS. [2020-12-21 14:23:38] [Kristian Andersen] There you go. It's time we go back to Andrew's London sewage theory. [2020-12-21 14:26:02] [Kristian Andersen] @Andrew Rambaut - do you have a good reference for the best "Wales" lineages? [2020-12-21 14:26:34] [Andrew Rambaut] You mean what muts it has? [2020-12-21 14:27:25] [Kristian Andersen] A GISAID ID? Creating an alignment for Andrew Ward so he can get a cryo guy on it and he wanted a prioritized list of sequences [2020-12-21 14:29:49] [Robert Garry] https://www.propublica.org/article/here-are-six-accidents-unc-researchers-had-with-lab-created-coronaviruses"*April 2020*: A UNC scientist underwent 14 days of self-quarantine at home after a mouse bite caused potential exposure to a strain of SARS-CoV-2, the virus that causes COVID-19, that had been adapted for growth in mice. The incident in a biosafety level 3 lab happened when a researcher attempted to read the ID number on a tag on a mouse's ear. The mouse flipped over in the researcher's hand and bit an index finger through two layers of gloves. It did not appear to break the researcher's skin, but UNC told NIH in its reports that "given the uncertainty surrounding the exposure, we are treating this as a medium/high risk exposure." The researcher was instructed to self-quarantine and do twice-daily temperature checks. UNC also notified the local Health Department. No further information about the worker's health was included in the incident reports." [2020-12-21 14:30:09] [Andrew Rambaut] Very confusingly (and coincidentally) it is lineage B.1.1.70 [2020-12-21 14:30:24] [Andrew Rambaut] Here are all the mutations from Wuhan: Spike D614G, Spike N501Y, N G204R, N Q9H, N R203K, NS3 Y156C, NS7a T14I, NSP3 H1539Y, NSP3 S126L, NSP5 G71S, NSP5 P132L, NSP12 P323L, NSP15 A217V, NSP15 M271I, NSP15 T33I [2020-12-21 14:30:36] [Andrew Rambaut] EPI_ISL_710967 [2020-12-21 14:30:46] [Kristian Andersen] Awesome - thanks