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Slack / Private Message Drop, p.334 [SLACK_000548] · slack_pm:msg:03518

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2/3 mutations associated with rodents?

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2020-12-21 14:06 Robert F. Garry open

Actually might be good to ask about for others that are adapting SC2 to mice - we've got a few groups here as well. Baric got Q493K by passing SC2 in mice. https://www.cell.com/cell/fulltext/S0092-8674(20)31247-2?rss=yes It was Sun et al. got N501Y, Q493H, and K417N. https://www.biorxiv.org/content/10.1101/2020.11.10.377333v1
2020-12-21 14:08 Kristian G. Andersen open

E484K - yeah, I _do_ wonder if there's some weird synergy going on between mutations here - I have a hard time believing all of this is down to 501 alone. But hey :man-shrugging:
2020-12-21 14:08 Andrew Rambaut open

They also have K417N in ZA
2020-12-21 14:09 Kristian G. Andersen open

Heh. Oooookay.
2020-12-21 14:09 Kristian G. Andersen

2/3 mutations associated with rodents?
2020-12-21 14:11 Kristian G. Andersen open

Yeah, so SA is K417N and N501Y - SA/UK both Q493
2020-12-21 14:12 Kristian G. Andersen open

So really major amino acid changes in the few they have - flipping around charges, etc.
2020-12-21 14:13 Kristian G. Andersen open

That E484K gotta be making some major differences in the structure
2020-12-21 14:19 Robert F. Garry open

Going full in: the FCS of some strains of mouse hepatitis virus is *H*RARRS.