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Slack / Private Message Drop, p.334 [SLACK_000548] · slack_pm:msg:03514

Date: 2020-12-21 14:06
Type: chat message · slack
recipient: Kristian G. Andersen, Edward C. Holmes, Andrew Rambaut
speaker: Robert F. Garry

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Actually might be good to ask about for others that are adapting SC2 to mice - we've got a few groups here as well. Baric got Q493K by passing SC2 in mice. https://www.cell.com/cell/fulltext/S0092-8674(20)31247-2?rss=yes It was Sun et al. got N501Y, Q493H, and K417N. https://www.biorxiv.org/content/10.1101/2020.11.10.377333v1

Links shared

journal https://www.cell.com/cell/fulltext/S0092-8674(20)31247-2?rss=yes
preprint https://www.biorxiv.org/content/10.1101/2020.11.10.377333v1

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2020-12-21 14:05 Kristian G. Andersen open

Bob, from the paper above - really does seem 501 is a key 'transmission' residue. Of course, 501T has also been observed.
2020-12-21 14:05 Andrew Rambaut open

It wouldn't be a simple epizootic - extensive transmission in mink didn't produce more than a few mutations
2020-12-21 14:06 Kristian G. Andersen open

Mink > rodents > humans - or some weird shit. But yeah, I agree - not consistent with what has been observedin mink and fully consistent with what has been observed in chronic infections.
2020-12-21 14:06 Andrew Rambaut open

South Africa are really worried about E484K (in conjunction with 501Y)
2020-12-21 14:06 Robert F. Garry

Actually might be good to ask about for others that are adapting SC2 to mice - we've got a few groups here as well. Baric got Q493K by passing SC2 in mice. https://www.cell.com/cell/fulltext/S0092-8674(20)31247-2?rss=yes It was Sun et al. got N501Y, Q493H, and K417N. https://www.biorxiv.org/content/10.1101/2020.11.10.377333v1
2020-12-21 14:08 Kristian G. Andersen open

E484K - yeah, I _do_ wonder if there's some weird synergy going on between mutations here - I have a hard time believing all of this is down to 501 alone. But hey :man-shrugging:
2020-12-21 14:08 Andrew Rambaut open

They also have K417N in ZA
2020-12-21 14:09 Kristian G. Andersen open

Heh. Oooookay.
2020-12-21 14:09 Kristian G. Andersen open

2/3 mutations associated with rodents?

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