Chat message

Slack / Private Message Drop, p.318 [SLACK_000532] · slack_pm:msg:03344

Date: 2020-12-16 04:41
Type: chat message · slack
recipient: Kristian G. Andersen, Robert F. Garry, Edward C. Holmes
speaker: Andrew Rambaut

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Yes - I am really convinced it is spreading because of these mutations not despite. And I am usually very cautious. Iam keeping my eye on a lineage with N501Y and none of the other mutations that is also spreading in the UK.

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2020-12-16 04:12 Robert F. Garry open

If the change in the FCS makes it somehow better able to infect the upper airways this could impact spread. Mightbe reflected in lower Ct values in nasal swabs.
2020-12-16 04:33 Robert F. Garry open

Doug's (D614G) daughter Nancy (N501Y) is certainly interesting - the deletion in the NTD along with the change near/in the RBD plus the rare FCS mutation are very likely driving some phenotype.
2020-12-16 04:41 Andrew Rambaut

Yes - I am really convinced it is spreading because of these mutations not despite. And I am usually very cautious. Iam keeping my eye on a lineage with N501Y and none of the other mutations that is also spreading in the UK.

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