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Slack / Private Message Drop, p.299 [SLACK_000513] · slack_pm:msg:03120

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How interesting... Yeah, that's a pango mutation

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2020-12-06 11:03 Andrew Rambaut open

Sampled in WA on 19-Jan
2020-12-06 11:04 Kristian G. Andersen open

I don't have my annotations right - which one is the non-synonymous change? Position 18060, which is the one thatdistinguishes WA1 from WH04 is the same in SARS as it is in WA1/RaTG13 (T)
2020-12-06 11:04 Andrew Rambaut open

One other possibility - hCoV-19/Malaysia/MKAK-CL-2020-6430/2020|EPI_ISL_416886|2020-02-04 is one SNP from WA1. Pangolin connection?
2020-12-06 11:07 Andrew Rambaut open

18060 is synon.
2020-12-06 11:09 Kristian G. Andersen

How interesting... Yeah, that's a pango mutation
2020-12-06 11:09 Andrew Rambaut open

The non-synon one is the one is 28189 in ORF8 S->L
2020-12-06 11:10 Andrew Rambaut open

That was the first 'oh my god it is mutating' mutation
2020-12-06 11:10 Kristian G. Andersen open

Haha, historical significance for sure :wink:
2020-12-06 11:11 Kristian G. Andersen open

All of this is very interesting though - isn't this data most consistent with an early divergence (or two emergences)that we didn't capture at the time and that have no connection to the seafood market? In other words - entirely what one might expect?