Slack / Private Message Drop — page 299

I think we know that WA1 travelled from Hubei (need to check) so that places the WA1 haplotype in Hubei [2020-12-06 11:02:37] [Kristian Andersen] Yup. [2020-12-06 11:03:52] [Andrew Rambaut] Sampled in WA on 19-Jan [2020-12-06 11:04:12] [Kristian Andersen] I don't have my annotations right - which one is the non-synonymous change? Position 18060, which is the one that distinguishes WA1 from WH04 is the same in SARS as it is in WA1/RaTG13 (T) [2020-12-06 11:04:52] [Andrew Rambaut] One other possibility - hCoV-19/Malaysia/MKAK-CL-2020-6430/2020|EPI_ISL_416886|2020-02-04 is one SNP from WA1. Pangolin connection? [2020-12-06 11:07:36] [Andrew Rambaut] 18060 is synon. [2020-12-06 11:09:28] [Kristian Andersen] How interesting... Yeah, that's a pango mutation [2020-12-06 11:09:32] [Andrew Rambaut] The non-synon one is the one is 28189 in ORF8 S->L [2020-12-06 11:10:04] [Andrew Rambaut] That was the first 'oh my god it is mutating' mutation [2020-12-06 11:10:26] [Kristian Andersen] Haha, historical significance for sure :wink: [2020-12-06 11:11:44] [Kristian Andersen] All of this is very interesting though - isn't this data most consistent with an early divergence (or two emergences) that we didn't capture at the time and that have no connection to the seafood market? In other words - entirely what one might expect? [2020-12-06 11:11:46] [Andrew Rambaut] Oh - I have just seen what you just said - Malaysia is the same as the Pangolin at 6049 where it differes from WA1 [2020-12-06 11:11:56] [Kristian Andersen] Yup [2020-12-06 11:12:21]