COVID-19 Records

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Slack / Private Message Drop, p.299 [SLACK_000513] · slack_pm:msg:03118

Page text: p.299 · original PDF

Date
2020-12-06 11:04
Type
chat message · slack
recipient
Kristian G. Andersen, Robert F. Garry, Edward C. Holmes
speaker
Andrew Rambaut
Topics
Natural origin / zoonotic spillover

Recipients on this medium are inferred from channel membership, not per-message addressing.

One other possibility - hCoV-19/Malaysia/MKAK-CL-2020-6430/2020|EPI_ISL_416886|2020-02-04 is one SNP from WA1. Pangolin connection?

In context

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  1. 2020-12-06 11:00 Andrew Rambaut open
    I think we know that WA1 travelled from Hubei (need to check) so that places the WA1 haplotype in Hubei
  2. 2020-12-06 11:02 Kristian G. Andersen open
    Yup.
  3. 2020-12-06 11:03 Andrew Rambaut open
    Sampled in WA on 19-Jan
  4. 2020-12-06 11:04 Kristian G. Andersen open
    I don't have my annotations right - which one is the non-synonymous change? Position 18060, which is the one thatdistinguishes WA1 from WH04 is the same in SARS as it is in WA1/RaTG13 (T)
  5. 2020-12-06 11:04 Andrew Rambaut
    One other possibility - hCoV-19/Malaysia/MKAK-CL-2020-6430/2020|EPI_ISL_416886|2020-02-04 is one SNP from WA1. Pangolin connection?
  6. 2020-12-06 11:07 Andrew Rambaut open
    18060 is synon.
  7. 2020-12-06 11:09 Kristian G. Andersen open
    How interesting... Yeah, that's a pango mutation
  8. 2020-12-06 11:09 Andrew Rambaut open
    The non-synon one is the one is 28189 in ORF8 S->L
  9. 2020-12-06 11:10 Andrew Rambaut open
    That was the first 'oh my god it is mutating' mutation

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