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Slack / Private Message Drop, p.293 [SLACK_000507] · slack_pm:msg:03051

Page text: p.293 · original PDF

Date
2020-12-04 07:49
Type
chat message · slack
recipient
Kristian G. Andersen, Edward C. Holmes, Andrew Rambaut
speaker
Robert F. Garry
Topics
Vaccines

Recipients on this medium are inferred from channel membership, not per-message addressing.

https://www.usatoday.com/story/news/health/2020/12/04/vaccine-ethics-does-continuing-covid-19-trials-put-volunteers-risk/6473436002/ This was one reason I advocated for human challenge trials - those in the placebo arm remain "sitting ducks."

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https://www.usatoday.com/story/news/health/2020/12/04/vaccine-ethics-does-continuing-covid-19-trials-put-volunteers-risk/6473436002/ This was one reason I advocated for human challenge trials - those in the placebo arm remain "sitting ducks." quoted / not their view quoted_external sentence carries quotation marks asserts

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  1. 2020-12-04 07:49 Robert F. Garry
    https://www.usatoday.com/story/news/health/2020/12/04/vaccine-ethics-does-continuing-covid-19-trials-put-volunteers-risk/6473436002/ This was one reason I advocated for human challenge trials - those in the placebo arm remain "sitting ducks."
  2. 2020-12-04 08:28 Andrew Rambaut open
    The Wellcome Trust is funding a challenge trial. They have manufactured the virus. I don't which vaccines they intend to use.
  3. 2020-12-04 09:12 Robert F. Garry open
    GOOD! A major question that randomized "wild" trials will struggle to answer is whether vaccinees still produce enough virus to remain infectious if exposed. Contrary to what I thought would be the case we found at Tulane that virus load had very little impact on whether or not a student was a "spreader." There was not complete sterilizingimmunity in the NHP challenge trials AFAIK. So, you could have a situation where vaccinees are protected against serious disease, but are still able to transmit the virus to some degree.
  4. 2020-12-04 09:17 Kristian G. Andersen open
    Damn IgA vs IgG! As for sterilizing immunity - the animal trials for both the J&J and RNA vaccines were promising on this aspect -the Oxford vaccine, not at all.
  5. 2020-12-04 09:18 Andrew Rambaut open
    But the RNA vaccines may recombine with your viruses and integrate into your genome and all sorts of things.

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