Chat message

Slack / Private Message Drop, p.282 [SLACK_000496] · slack_pm:msg:02929

Date: 2020-11-27 10:42
Type: chat message · slack
recipient: Kristian G. Andersen, Robert F. Garry, Edward C. Holmes
speaker: Andrew Rambaut
Topics: Furin cleavage site and molecular features

Recipients on this medium are inferred from channel membership, not per-message addressing.

@Andrew Rambaut Could be something to touch on in the PO2. Some of the RBD mutations we have seen recently (eg mink) are actually reversions to the bat residues.

Extracted statements

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Statement	Grade	Attribution	Stance
Some of the RBD mutations we have seen recently (eg mink) are actually reversions to the bat residues.	own voice, substantive	speaker_own	asserts

Statement

Grade

Attribution

Stance

Some of the RBD mutations we have seen recently (eg mink) are actually reversions to the bat residues.

own voice, substantive

speaker_own

asserts

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2020-11-27 10:35 Andrew Rambaut open

Pretty much sure the MRCA of all circulating viruses we have sample so far was one or other of the two original haplotypes. But seems likely to me that it came in to wuhan from somewhere else in China.
2020-11-27 10:36 Andrew Rambaut open

shared file(s): Image from iOS.jpg
2020-11-27 10:38 Kristian G. Andersen open

@Andrew Rambaut But that mid-point rooting though..?
2020-11-27 10:41 Kristian G. Andersen open

[desperately trying to find that old Tweet he sent to Oli... I will persevere!]
2020-11-27 10:42 Andrew Rambaut

@Andrew Rambaut Could be something to touch on in the PO2. Some of the RBD mutations we have seen recently (eg mink) are actually reversions to the bat residues.
2020-11-27 10:42 Kristian G. Andersen open

Here it is - it's a true piece of beautiful Twitter history. Nice guy. [shared file(s): 61ED1770-AF57-4BE4-B916-1ED34005C3C6.jpg]
2020-11-27 10:43 Andrew Rambaut open

@Andrew Rambaut But of course that is with a non-ACE2 RBD in bats.
2020-11-27 10:44 Kristian G. Andersen open

@Andrew Rambaut Yeah, I definitely think this is something to touch on - I have been intrigued by this question for along time, but haven't had time to take a closer look (plus, I'm really not the best to look at this question in any case).
2020-11-27 10:44 Kristian G. Andersen open

@Andrew Rambaut Let's maybe wait until we get some more pangos and then look a little closer at the root plus what's going on in mink in terms of reversions?

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