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Slack / Private Message Drop, p.282 [SLACK_000496] · slack_pm:msg:02927

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@Andrew Rambaut But that mid-point rooting though..?

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A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2020-11-27 10:35 Andrew Rambaut open

Pretty much sure the MRCA of all circulating viruses we have sample so far was one or other of the two original haplotypes. But seems likely to me that it came in to wuhan from somewhere else in China.
2020-11-27 10:36 Andrew Rambaut open

shared file(s): Image from iOS.jpg
2020-11-27 10:38 Kristian G. Andersen

@Andrew Rambaut But that mid-point rooting though..?
2020-11-27 10:41 Kristian G. Andersen open

[desperately trying to find that old Tweet he sent to Oli... I will persevere!]
2020-11-27 10:42 Andrew Rambaut open

@Andrew Rambaut Could be something to touch on in the PO2. Some of the RBD mutations we have seen recently (eg mink) are actually reversions to the bat residues.
2020-11-27 10:42 Kristian G. Andersen open

Here it is - it's a true piece of beautiful Twitter history. Nice guy. [shared file(s): 61ED1770-AF57-4BE4-B916-1ED34005C3C6.jpg]
2020-11-27 10:43 Andrew Rambaut open

@Andrew Rambaut But of course that is with a non-ACE2 RBD in bats.