Private channel session 618

9 messages over 8m, 2020-11-27 – 2020-11-27.

A “conversation” here is an activity session — a run of messages with under 60 minutes of silence inside it. The channel had no native conversation boundaries.

2020-11-27 10:35 Andrew Rambaut open PDF p.281

Pretty much sure the MRCA of all circulating viruses we have sample so far was one or other of the two original haplotypes. But seems likely to me that it came in to wuhan from somewhere else in China.
2020-11-27 10:36 Andrew Rambaut open PDF p.282

shared file(s): Image from iOS.jpg
2020-11-27 10:38 Kristian G. Andersen open PDF p.282

@Andrew Rambaut But that mid-point rooting though..?
2020-11-27 10:41 Kristian G. Andersen open PDF p.282

[desperately trying to find that old Tweet he sent to Oli... I will persevere!]
2020-11-27 10:42 Andrew Rambaut open PDF p.282

@Andrew Rambaut Could be something to touch on in the PO2. Some of the RBD mutations we have seen recently (eg mink) are actually reversions to the bat residues.
2020-11-27 10:42 Kristian G. Andersen open PDF p.282

Here it is - it's a true piece of beautiful Twitter history. Nice guy. [shared file(s): 61ED1770-AF57-4BE4-B916-1ED34005C3C6.jpg]
2020-11-27 10:43 Andrew Rambaut open PDF p.282

@Andrew Rambaut But of course that is with a non-ACE2 RBD in bats.
2020-11-27 10:44 Kristian G. Andersen open PDF p.282

@Andrew Rambaut Yeah, I definitely think this is something to touch on - I have been intrigued by this question for along time, but haven't had time to take a closer look (plus, I'm really not the best to look at this question in any case).
2020-11-27 10:44 Kristian G. Andersen open PDF p.282

@Andrew Rambaut Let's maybe wait until we get some more pangos and then look a little closer at the root plus what's going on in mink in terms of reversions?