COVID-19 Records

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Slack / Private Message Drop, p.249 [SLACK_000463] · slack_pm:msg:02596

Page text: p.249 · original PDF

Date
2020-11-04 14:29
Type
chat message · slack
recipient
Kristian G. Andersen, Robert F. Garry, Edward C. Holmes
speaker
Andrew Rambaut
Topics
Furin cleavage site and molecular features

Recipients on this medium are inferred from channel membership, not per-message addressing.

Actually, I have some inside information from WHO (please keep confidential): > We have tested a variant with four simultaneous changes in the spike protein (Amino acid changes: 69del, Y453F, I692V, M1229I). This variant has been found in five minkfarms and also in humans in the surrounding community. A complete GISAID upload of all Danish Sars-CoV-2 sequences of human origin is planned for the end of week 45. We have cultured this virus from a human patient and evaluated whether it was sensitive to neutralizing antibodies (antisera) from a collection of sera from convalescent COVID-19 patients. We found that this virus showed less sensitivity (resistance) for neutralizing antibodies from persons with previous COVID-19 infection.

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Actually, I have some inside information from WHO (please keep confidential): > We have tested a variant with four simultaneous changes in the spike protein (Amino acid changes: 69del, Y453F, I692V, M1229I). own voice, substantive speaker_own asserts

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  1. 2020-11-04 14:29 Andrew Rambaut
    Actually, I have some inside information from WHO (please keep confidential): > We have tested a variant with four simultaneous changes in the spike protein (Amino acid changes: 69del, Y453F, I692V, M1229I). This variant has been found in five minkfarms and also in humans in the surrounding community. A complete GISAID upload of all Danish Sars-CoV-2 sequences of human origin is planned for the end of week 45. We have cultured this virus from a human patient and evaluated whether it was sensitive to neutralizing antibodies (antisera) from a collection of sera from convalescent COVID-19 patients. We found that this virus showed less sensitivity (resistance) for neutralizing antibodies from persons with previous COVID-19 infection.
  2. 2020-11-04 14:29 Andrew Rambaut open
    Why they are not releasing this information and the data I don't know.
  3. 2020-11-04 14:53 Edward C. Holmes open
    Interesting. Looking forward to the press on this one.
  4. 2020-11-04 15:03 Robert F. Garry open
    Opinion: To stop the next pandemic, we need to unravel the origins of COVID-19 View ORCID Profile David A. Relman PNAS first published November 3, 2020; https://doi.org/10.1073/pnas.2021133117

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