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Slack / Private Message Drop, p.250 [SLACK_000464] · slack_pm:msg:02599

Page text: p.250 · original PDF

Date
2020-11-04 15:03
Type
chat message · slack
recipient
Kristian G. Andersen, Edward C. Holmes, Andrew Rambaut
speaker
Robert F. Garry

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Opinion: To stop the next pandemic, we need to unravel the origins of COVID-19 View ORCID Profile David A. Relman PNAS first published November 3, 2020; https://doi.org/10.1073/pnas.2021133117

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  1. 2020-11-04 14:29 Andrew Rambaut open
    Actually, I have some inside information from WHO (please keep confidential): > We have tested a variant with four simultaneous changes in the spike protein (Amino acid changes: 69del, Y453F, I692V, M1229I). This variant has been found in five minkfarms and also in humans in the surrounding community. A complete GISAID upload of all Danish Sars-CoV-2 sequences of human origin is planned for the end of week 45. We have cultured this virus from a human patient and evaluated whether it was sensitive to neutralizing antibodies (antisera) from a collection of sera from convalescent COVID-19 patients. We found that this virus showed less sensitivity (resistance) for neutralizing antibodies from persons with previous COVID-19 infection.
  2. 2020-11-04 14:29 Andrew Rambaut open
    Why they are not releasing this information and the data I don't know.
  3. 2020-11-04 14:53 Edward C. Holmes open
    Interesting. Looking forward to the press on this one.
  4. 2020-11-04 15:03 Robert F. Garry
    Opinion: To stop the next pandemic, we need to unravel the origins of COVID-19 View ORCID Profile David A. Relman PNAS first published November 3, 2020; https://doi.org/10.1073/pnas.2021133117

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