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Slack / Private Message Drop, pp.137-138 [SLACK_000351] · slack_pm:msg:01407

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I will take another look before our chat.

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2020-08-15 16:06 Kristian G. Andersen open

And yes, from a probability standpoint - two separate outbreaks starting essentially at the same time? Clearly not impossible, but definitely seems risk overall is just up for Ebola - people encroaching on animal habitat I guess.
2020-08-15 16:07 Andrew Rambaut open

I wouldn't trust the basal thing - it has lots of low coverage areas including over quite a few SNPS internal to the outbreak.
2020-08-15 16:08 Andrew Rambaut open

Strong ascertainment bias - EVD will be noticed in that area.
2020-08-15 16:08 Kristian G. Andersen open

Ah, okay - I asked Mike if that sequence had any of the human diversity from the previous outbreak and he said no.But if it's a low coverage sample, who knows. Very very interesting (and so messed up...)
2020-08-15 16:09 Andrew Rambaut

I will take another look before our chat.
2020-08-15 16:10 Kristian G. Andersen open

Also, interestingly - more cases of vaccinees getting primary Ebola, only to relapse later on after having receivedmAbs... This definitely needs some further looking into.
2020-08-15 16:15 Andrew Rambaut open

Yeah, not coming out basal for me... [shared file(s): image.png]
2020-08-15 16:17 Andrew Rambaut open

Don't have all the 2018 genomes there for some reason.
2020-08-15 16:26 Edward C. Holmes open

Very weird indeed. Can we rule out a fuck-up?