A single line often inverts meaning once you see what it
answers, so neighbouring messages are always shown.
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:bat:/n Eddie: 80/20 Kristian: 70/30
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90/10. I think.
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Strictly confidentially, I literally (2 mins ago) just got an email that says: "Recently, we isolated a pangolin-Cov that ishighly related with SARS-CoV-2 (https://www.nature.com/articles/s41586-020-2313-x). We further found that the infected pangolins showed similar CT scans with COVID-19 patients (please see the attachment, a and b are virus-positive pangolins, while c is virus-negative). Thus, we further did the transcriptome of their multiple tissue, and found they showed similar immune response as that of COVID-19 patients, that is, an inadequate interferonresponse, but excessive inflammatory response and an over-exuberant cytokine response.In addition, we found other interesting results". I don't the viruses are any closer to the ones we have but the clinical/transcriptome results are interesting...if true (you can never tell) would you expect a clinically similar infection in an animal in nature if this had come out of a lab?
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2020-06-11 20:38
Edward C. Holmes
I will of course agree to help to see what more I can discover.
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> would you expect a clinically similar infection in an animal in nature if this had come out of a lab? Don't think one would have an expectation one way or the other - but interesting nonetheless. I find it peculiar that all these pangolins are showing up sick with all sorts of SARS-like CoVs though - I mean, these guys have been traded_forever_ and only now do we realize they have CoVs? Potentially a huge reservoir out there... which is scary.
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Agreed. No one gives a shit and now we are seeing loads of pangolins with frothy lungs. You couldn't make this up.
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Notable that HKU1 does have a furin cleavage site but NL63 doesn't. To me, this trait moves around so much in nature that we can't really say anything: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866027/
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And they weren't able to culture HKU1.