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Slack / Private Message Drop, p.73 [SLACK_000287] · slack_pm:msg:00739

Page text: p.73 · original PDF

Date
2020-06-11 20:14
Type
chat message · slack
recipient
Robert F. Garry, Edward C. Holmes, Andrew Rambaut
speaker
Kristian G. Andersen

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:bat:/n Eddie: 80/20 Kristian: 70/30

In context

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  1. 2020-06-11 20:14 Kristian G. Andersen
    :bat:/n Eddie: 80/20 Kristian: 70/30
  2. 2020-06-11 20:34 Edward C. Holmes open
    90/10. I think.
  3. 2020-06-11 20:37 Edward C. Holmes open
    Strictly confidentially, I literally (2 mins ago) just got an email that says: "Recently, we isolated a pangolin-Cov that ishighly related with SARS-CoV-2 (https://www.nature.com/articles/s41586-020-2313-x). We further found that the infected pangolins showed similar CT scans with COVID-19 patients (please see the attachment, a and b are virus-positive pangolins, while c is virus-negative). Thus, we further did the transcriptome of their multiple tissue, and found they showed similar immune response as that of COVID-19 patients, that is, an inadequate interferonresponse, but excessive inflammatory response and an over-exuberant cytokine response.In addition, we found other interesting results". I don't the viruses are any closer to the ones we have but the clinical/transcriptome results are interesting...if true (you can never tell) would you expect a clinically similar infection in an animal in nature if this had come out of a lab?
  4. 2020-06-11 20:38 Edward C. Holmes open
    I will of course agree to help to see what more I can discover.
  5. 2020-06-11 21:26 Kristian G. Andersen open
    > would you expect a clinically similar infection in an animal in nature if this had come out of a lab? Don't think one would have an expectation one way or the other - but interesting nonetheless. I find it peculiar that all these pangolins are showing up sick with all sorts of SARS-like CoVs though - I mean, these guys have been traded_forever_ and only now do we realize they have CoVs? Potentially a huge reservoir out there... which is scary.

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