Chat message

Slack / Private Message Drop, p.73 [SLACK_000287] · slack_pm:msg:00741

Date: 2020-06-11 20:37
Type: chat message · slack
recipient: Kristian G. Andersen, Robert F. Garry, Andrew Rambaut
speaker: Edward C. Holmes
Topics: Natural origin / zoonotic spillover

Recipients on this medium are inferred from channel membership, not per-message addressing.

Strictly confidentially, I literally (2 mins ago) just got an email that says: "Recently, we isolated a pangolin-Cov that ishighly related with SARS-CoV-2 (https://www.nature.com/articles/s41586-020-2313-x). We further found that the infected pangolins showed similar CT scans with COVID-19 patients (please see the attachment, a and b are virus-positive pangolins, while c is virus-negative). Thus, we further did the transcriptome of their multiple tissue, and found they showed similar immune response as that of COVID-19 patients, that is, an inadequate interferonresponse, but excessive inflammatory response and an over-exuberant cytokine response.In addition, we found other interesting results". I don't the viruses are any closer to the ones we have but the clinical/transcriptome results are interesting...if true (you can never tell) would you expect a clinically similar infection in an animal in nature if this had come out of a lab?

Links shared

journal https://www.nature.com/articles/s41586-020-2313-x

Extracted statements

Rule-extracted, not adjudicated. The grade says what may be done with each one; read the document above before relying on any of them.

Statement	Grade	Attribution	Stance
Strictly confidentially, I literally (2 mins ago) just got an email that says: "Recently, we isolated a pangolin-Cov that ishighly related with SARS-CoV-2 (https://www.nature.com/articles/s41586-020-2313-x).	own voice, substantive	speaker_own	asserts
We further found that the infected pangolins showed similar CT scans with COVID-19 patients (please see the attachment, a and b are virus-positive pangolins, while c is virus-negative).	quoted / not their view	quoted_external inside quotation marks	asserts

Statement

Grade

Attribution

Stance

own voice, substantive

speaker_own

asserts

We further found that the infected pangolins showed similar CT scans with COVID-19 patients (please see the attachment, a and b are virus-positive pangolins, while c is virus-negative).

quoted / not their view

quoted_external inside quotation marks

asserts

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2020-06-11 20:14 Kristian G. Andersen open

:bat:/n Eddie: 80/20 Kristian: 70/30
2020-06-11 20:34 Edward C. Holmes open

90/10. I think.
2020-06-11 20:37 Edward C. Holmes

Strictly confidentially, I literally (2 mins ago) just got an email that says: "Recently, we isolated a pangolin-Cov that ishighly related with SARS-CoV-2 (https://www.nature.com/articles/s41586-020-2313-x). We further found that the infected pangolins showed similar CT scans with COVID-19 patients (please see the attachment, a and b are virus-positive pangolins, while c is virus-negative). Thus, we further did the transcriptome of their multiple tissue, and found they showed similar immune response as that of COVID-19 patients, that is, an inadequate interferonresponse, but excessive inflammatory response and an over-exuberant cytokine response.In addition, we found other interesting results". I don't the viruses are any closer to the ones we have but the clinical/transcriptome results are interesting...if true (you can never tell) would you expect a clinically similar infection in an animal in nature if this had come out of a lab?
2020-06-11 20:38 Edward C. Holmes open

I will of course agree to help to see what more I can discover.
2020-06-11 21:26 Kristian G. Andersen open

> would you expect a clinically similar infection in an animal in nature if this had come out of a lab? Don't think one would have an expectation one way or the other - but interesting nonetheless. I find it peculiar that all these pangolins are showing up sick with all sorts of SARS-like CoVs though - I mean, these guys have been traded_forever_ and only now do we realize they have CoVs? Potentially a huge reservoir out there... which is scary.
2020-06-11 21:40 Edward C. Holmes open

Agreed. No one gives a shit and now we are seeing loads of pangolins with frothy lungs. You couldn't make this up.
2020-06-11 21:47 Edward C. Holmes open

Notable that HKU1 does have a furin cleavage site but NL63 doesn't. To me, this trait moves around so much in nature that we can't really say anything: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866027/

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