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Slack / Private Message Drop, p.57 [SLACK_000271] · slack_pm:msg:00566

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SARS-CoV-2 strategically mimics proteolytic activation of human ENaC

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2020-06-06 02:28 Robert F. Garry open

https://elifesciences.org/articles/58603 a-subunit (ENaC-a) how looks in other species? Would be interesting to know a is?
2020-06-06 02:29 Robert F. Garry

SARS-CoV-2 strategically mimics proteolytic activation of human ENaC
2020-06-06 02:29 Robert F. Garry open

human epithelial sodium channel -subunit (ENaC-)
2020-06-06 02:38 Robert F. Garry open

Sorry - messed up the links above - the elife paper does a considerable amt of arm waving over an 8 amino acid homology -the furin site - but "interesting" that the furin site in both SARS-CoV-2 and ENaC- has predicted O-linked glycans PLUS ENaC- has another proline, serine, threonine rich stretch - a likely mucin domain - OC43 and HKU1 Spike also have this.
2020-06-06 02:51 Robert F. Garry open

"RTT plot for Ebola is super interesting" Agree - how do the RBDs align on the different branches?
2020-06-06 03:10 Edward C. Holmes open

Got it. I don't suppose we know much about how ENaC- how looks in other species? Would be interesting to know what species OC43 and HKU1 originated in.