Anthony S. Fauci

Much like a university endowment, the fund would have a two-tiered financial structure.

Diary Prequel Package, p.4 · original PDF · in context

April 11, 2001 - Attached below is what is to be the final document: Draft Privileged and Confidential For Official Use Only Infectious diseases, including HIV/AIDS, malaria, and tuberculosis, are ravaging developing nations, causing 25 percent of all deaths worldwide and eroding recent gains in economic growth, education, and life expectancy.

Diary Prequel Package, p.11 · original PDF · in context

We will give preference to comprehensive plans that involve governments and civil society working together. • We will link our efforts in health to expanded programs in the areas of education and nutrition in an international parallel to the Administration's campaign to "Leave No Child Behind." • We are committed to a policy of promoting intellectual property protection, including for pharmaceutical patents, because of its critical role in the rapid innovation, development, and commercialization of effective and safe drug therapies and vaccines.

Diary Prequel Package, p.11 · original PDF · in context

With more than 50 years of experience with health projects and a proven institutional capacity to manage large financial transactions, the World Bank should serve as the fiscal agent for the Fund.

Diary Prequel Package, p.11 · original PDF · in context

A small Executive Secretariat housed at the Bank and jointly staffed by the Bank, UNAIDS and the World Health Organization would undertake the day-to-day management of the trust fund, including soliciting grant proposals.

Diary Prequel Package, p.11 · original PDF · in context

The Council would fully control all fund decisions, including determining programmatic allocations, operational rules and procedures, policies and strategies, approving financial plans and work programs, and attracting additional donations.

Diary Prequel Package, p.11 · original PDF · in context

Much like a university endowment, the fund would have a two-tiered financial structure.

Diary Prequel Package, p.11 · original PDF · in context

What really, truely, is the statistically valid efficacy of HAART? - In terms of the pentultimate concern that I believe (I hope) is the bottom line for all sides --- SAVING LIVES --- what would be the impact of a massive spending commitment aimed at: - cleaning up the blood supply (less than 10% of which globally, according to WHO, is currently screened for Hep B, C and HIV) - global large scale distribution of autodestruct nonreuseable syringes and MANDATORY coupling of all injectable drug and vaccine products with such syringes.

Diary Prequel Package, p.18 · original PDF · in context

We were shown around by Laura Guay and Phillip Musoke Mudido, a Ugandan physician.

Diary Prequel Package, p.23 · original PDF · in context

Like Nelson Sewankambo, Peter is clearly an important physician in Uganda and the JCRC does much clinical research on HIV/AIDS.

Diary Prequel Package, p.23 · original PDF · in context

Most Staff (PH.Ds, MDs, MPHs and even technicians have spent some time learning techniques and theory in the USA.

Diary Prequel Package, p.23 · original PDF · in context

The site was inspiring, particularly the dedication of the staff who were mostly young Ugandan MDs, PH.Ds, technicians, nurses, etc.

Diary Prequel Package, p.23 · original PDF · in context

I was told that among their other diseases such as HIV and TB, the majority of the people in the wards, especially the children, had malaria.

Diary Prequel Package, p.23 · original PDF · in context

We crafted something that was a "high road" approach indicating that since we cannot enforce restrictions among committed users and abusers, then at least we can support biomedical research to provide better diagnostics, therapeutics and vaccines.

Diary Prequel Package, p.31 · original PDF · in context

This was in association with Time Magazine naming me one of 18 scientists as "America's Best in Science and Medicine".

Diary Prequel Package, p.32 · original PDF · in context

Ridge the truth or he is masking the truth.

Diary Prequel Package, p.35 · original PDF · in context

Someone at that meeting leaked this to the NY Times and Sheryl Stolberg called me and heard that I had "angrily confronted the FBI for withholding information".

Diary Prequel Package, p.36 · original PDF · in context

If the person has large amounts, he would have to have special facilities or would have to have gotten it from a rogue state or covertly from USA .

Diary Prequel Package, p.37 · original PDF · in context

In any event, Gayle assured me that the Op-Ed was not "off message" in the substance of its content.

Diary Prequel Package, p.262 · original PDF · in context

Dec.15, 2001 - Sat. meeting at NAS regarding recommendations of giving anthrax vaccine to people who were exposed to anthrax and who are just finishing their 60 course of antibiotics.

Diary Prequel Package, p.41 · original PDF · in context

It is true that there is a "theoretical" reason to make the vaccine available in that animal studies show persistence of spores weeks after antibiotics and there is a fear that after antibiotics are discontinued the disease will occur.

Diary Prequel Package, p.41 · original PDF · in context

However, Eisold and the Senate Staffers are demanding that they get the anthrax vaccine.

Diary Prequel Package, p.41 · original PDF · in context

Henderson and Tommy Thompson had told Daschle that the vaccine would be available 2 days ago.

Diary Prequel Package, p.41 · original PDF · in context

I have insisted that if I am going to help we must not "recommend" the vaccine since the data in animals show that it is not better than antibiotics alone.

Diary Prequel Package, p.41 · original PDF · in context

She states that the White House says that the reason is the objection to the 2 jobs, while the social conservatives say that my views on abortion and stem cells make me unacceptable to them.

Diary Prequel Package, p.44 · original PDF · in context

Also, in same issue of NEJM was my editorial calling for an open dialogue as to whether there should be pre-emptive vaccination of "first responders" or even of the enitre population on a voluntary basis.

Diary Prequel Package, p.45 · original PDF · in context

Josh asked whether we should do a Manhattan Project for a vaccine and not invest in international prevention and treatment.

Diary Prequel Package, p.47 · original PDF · in context

Our plan for "staged" smallpox vaccination of immediate first responders to broad first responders to voluntary vaccination of general public is ready to go.

Diary Prequel Package, p.52 · original PDF · in context

The differences are even more impressive in the Table from the 2001 MMWR (attachment #3) 2) Since the differences are so striking between previously unvaccinated and previously vaccinated individuals with regard to the incidence of serious adverse events associated with smallpox vaccination, I calculated the percent of people in the work force that we could predict would be previously vaccinated or not.

Diary Prequel Package, p.55 · original PDF · in context

I mentioned that we should have a fund to purchase vaccines and drugs so that the pharmaceutical industry would have an incentive to get involved.

Diary Prequel Package, p.58 · original PDF · in context

This is different from the situation with the anthrax vaccine where the DHHS said that had no recommendation either way; they just made the vaccine available if people wanted it.

Diary Prequel Package, p.60 · original PDF · in context

I am relieved that we decided to wait since I would have had to cancel my going to Los Angeles to receive the RAND Prize ($10,000.00) in order to remain in DC for the Press.

Diary Prequel Package, p.61 · original PDF · in context

The VP wants to come to NIH and have me show him around the Vaccine Research Center (VRC) in the context of the "Advanced Project Development" of Project Bioshield.

Diary Prequel Package, p.64 · original PDF · in context

George pointed out that the President gave an interview with Barbara Walters to view on Dec. 13 in which he said that he would allow vaccination of the entire population on a voluntary basis.

Diary Prequel Package, p.64 · original PDF · in context

Big surprise in the statement was the fact that we will make vaccine available to the public before 2004 by allowing people who insist on vaccination to enter into an ongoing clinical trial (Cangene, Acambis, etc.) or by creating a special IND protocol (using Aventis-Pasteur).

Diary Prequel Package, p.64 · original PDF · in context

In the middle of the meeting, Scooter Libby called me on my cell phone and said that he was going into a meeting with the VP and the President at 1:00 PM (it was now 11:30 AM) and he needed for me to write a 1⁄2 pager on the concept of a mandatory fund for vaccine (he said trust fund, but we subsequently hashed out a Perm.

Diary Prequel Package, p.66 · original PDF · in context

She insisted that the original agreement was for vaccines only and not what she called "countermeasures" such as botulism antitoxin and Cidofovir, which were on the list.

Diary Prequel Package, p.67 · original PDF · in context

She did not understand that "Countermeasures" is the big umbrella under which are vaccines, antitoxins, etc.

Diary Prequel Package, p.67 · original PDF · in context

Amazingly, Nancy said that "look what happened with the smallpox vaccine.

Diary Prequel Package, p.67 · original PDF · in context

She considers the smallpox vaccine situation, which was one of the great successes of the year to be a failure since many Americans would opt not to take it.

Diary Prequel Package, p.67 · original PDF · in context

I had to leave at 7:00 PM to prepare for my Senate Hearing on Smallpox the next day.

Diary Prequel Package, p.70 · original PDF · in context

The President walked in during the meeting and greeted the Congressmen and gave me a special warm greeting saying that the "A" team was there.

Diary Prequel Package, p.72 · original PDF · in context

May 2, 2003 - Did "Field Hearing" in Harrisburg, PA for Sen.

Diary Prequel Package, p.76 · original PDF · in context

It was a Gala affair at the Mellon Auditorium in Washington, D.C.

Diary Prequel Package, p.76 · original PDF · in context

When I speak about vaccines I >almost always (with minor variations) talk about: 1) what the Federal >government, particularly NIAID is doing; 2) the need for a new look and >an accelerated effort, i.e. the Enterprise; and 3) the role that the >PAVE may play in the Enterprise.

Gates Package, p.272 · original PDF · in context

I will be at a meeting in Wye River on Saturday AM and >early afternoon, but I will be either in the office or home for the >rest of the weekend. >Best regards, >Tony > > << File: AIDS Vaccine Enterprise-PAVE.ppt >> > > -----Original Message-----

Gates Package, p.272 · original PDF · in context

He feels that if I go, he will arrange for CIA operatives to get me into the country and move around "under the radar" and that CIA operatives would provide my security.

Diary Prequel Package, p.83 · original PDF · in context

Note -- she was one of 3 wives of the husband who died last year of AIDS.

Diary Prequel Package, p.85 · original PDF · in context

Of the 7 children only 3 ver and the others were from the husbands other wives.

Diary Prequel Package, p.85 · original PDF · in context

She had just lost her 1 year old baby to AIDS and 2 of the other children of other wives were infected with HIV.

Diary Prequel Package, p.85 · original PDF · in context

The alignment of the motorcade was that every time we passed a person(s) walking along the highway or a parked car or truck, the special forces car would insert themselves between the suspects and TGT's car (I was riding with TGT).

Diary Prequel Package, p.89 · original PDF · in context

We passed cars driving with people or when cars pulled up alongside, the military police and special forces would wave them over and point their guns directly at the driver.

Diary Prequel Package, p.89 · original PDF · in context

I met with the Blue Ribbon Panel and urged them to distinguish between outside activities that could be conflictual such as consulting for drug companies and those that are purely academic such as writing, editing, lecturing (not on your immediate work) and awards.

Diary Prequel Package, p.93 · original PDF · in context

Decision was made to have Randy Tobias write and Op-Ed for The NY Times or the Washington Post (I will review it for him) and then have me and Randy as necessary do the TV circuit to get the truth out , i.e. that we will buy any drugs , even generics, so long as they are of high quality (safe and effective) and the lowest possible price.

Diary Prequel Package, p.95 · original PDF · in context

August 11, 2004 - Met at EEOB Room 283 with Carol Kuntz and Bruce Miller and Dorothy.... to discuss tentative plans to determine whether IL-4 gene inserted into monkeypox would have the same effect as IL-4 inserted into mousepox virus, i.e. it would suppress the immune response enough to allow lethal disease in the animal.

Diary Prequel Package, p.106 · original PDF · in context

Today, I had an official briefing at the White House for Carol Kuntz and Bruce Miller (her deputy) on research plans and strategy for countermeasures for "Genetically Engineered Microbes".

Diary Prequel Package, p.106 · original PDF · in context

Carol gave me a "redlined" copy of the Bioshield Legislation that was signed by President Bush and VP Cheney as a special gift from them to me due to my work on the development and passage of BioShield.

Diary Prequel Package, p.106 · original PDF · in context

Our FDA is correct since I was hearing the same thing.

Diary Prequel Package, p.108 · original PDF · in context

If we go with Canadian vaccine, this would have to be done by an IND since it is not licensed by FDA.

Diary Prequel Package, p.108 · original PDF · in context

Finally, I put the royalties on my financial disclosure statement (SF278), but OGE told me to take it off since it was equivalent to government salary that does not go on SF278.

Diary Prequel Package, p.113 · original PDF · in context

It would have been better if my name was not associated with any COI story, but at least he mentioned about giving the money to charity as well as the fact that I tried to put the amount on my financial statement.

Diary Prequel Package, p.113 · original PDF · in context

The Hearing was mostly blasting DoD for disorganization and "wasting money".

Diary Prequel Package, p.117 · original PDF · in context

We are in the final stages of finally officially firing Jonathan Fishbein.

Diary Prequel Package, p.117 · original PDF · in context

August 7, 2005 - Major Sunday news day with front page article in NY Times predominantly quoting me) regarding the successful preliminary data from the NIAIDfunded H5N1 vaccine trial that showed safety and an immune response that would be predictive of protection.

Diary Prequel Package, p.120 · original PDF · in context

Draft briefing materials for a major press conference advised the President to say that "as far as our best scientists have been able to determine, AIDS virus is not transmitted through casual or routine contact." Yet in his role as Associate Counsel to President Reagan, Mr.

Diary Prequel Package, p.122 · original PDF · in context

Roberts wrote that "we should assume that AIDS can be transmitted through casual or routine contact." Five days later, when asked whether it was safe for children with AIDS to go to school, President Reagan did not cite the nation's leading public health officials.

Diary Prequel Package, p.122 · original PDF · in context

He instead stated, "I can understand both sides of it." The President's failure to speak clearly about scientific understanding of AIDS transmission is now widely understood to have stoked the hysteria about AIDS and the social stigma suffered by children with AIDS.

Diary Prequel Package, p.122 · original PDF · in context

Roberts, who was then Associate Counsel to the President, advised a completely different approach.

Diary Prequel Package, p.124 · original PDF · in context

In that case, the Court held: In the context of the employment of a person handicapped with a contagious disease agree with the amicus American Medical Association that this inquiry should includ "findings of facts, based on reasonable medical judgments given the state of medical knowledge about the nature of the risk (how the disease is transmitted) ... and the probabilities the disease will be transmitted ...." In making these findings, courts normally should defer to the reasonable medical judgment of public health officials.

Diary Prequel Package, p.126 · original PDF · in context

Lewis "Scooter Libby" for perjury, obstruction of justice and making false statements in the er, and veil the investigation of the leak that Valerie Plame was a CIA agent.

Diary Prequel Package, p.134 · original PDF · in context

He agrees that we should give liability protection to the pharmaceutical companies to keep them in the business of influenza vaccine manufacturing.

Diary Prequel Package, p.135 · original PDF · in context

However, he feels that we must also provide compensation for those that might be injured by the vaccine.

Diary Prequel Package, p.135 · original PDF · in context

The meeting was unexpectedly enjoyable in that I went to "close-up" panel discussions, breakfasts etc with people like President Muschaaraf of Pakistan, President Karzai of Afghanistan, Bill Gates, Bono, Queen Rana of Jordan, Bill Clinton, a number of journalists, etc.

Diary Prequel Package, p.140 · original PDF · in context

The meeting was opened by Bill Clinton and Bill and Melinda Gates.

Diary Prequel Package, p.144 · original PDF · in context

I gave the Opening Ceremony Keynote lecture on the evening of Aug. 28 and provided a "provocative" talk on "An AIDS Vaccine: Will It Ever Fit the Classical Paradigm?" It was extremely well-received by an audience of about 1000.

Diary Prequel Package, p.144 · original PDF · in context

Guest were Sherry Lansing (Hollywood producer - "Fatal Attraction", Black Rain" and former actress) and her husband, Billy Friedken (Multiple Academy Award winning Producer, Director and Writer - "Exorcist", "The French Connection", etc. ) He is now producing (successfully) operas all over the world.

Diary Prequel Package, p.145 · original PDF · in context

Also there were Joe Wilson, the ambassador involved in the big Washington issue of the Administration "misleading" the American public about WMDs in Iraq and his wife Valerie Plame , the CIA secret agent that was "outted" by Robert Novack's column and for which Scooter Libby has been indicted for perjury.

Diary Prequel Package, p.145 · original PDF · in context

Joe, as he has said on TV multiple times, feels that the WH officials are all a "bunch of liars".

Diary Prequel Package, p.145 · original PDF · in context

It asked us to justify with all of our research why it should be unclassified making the default position that everything should be classified.

Diary Prequel Package, p.152 · original PDF · in context

May 24, 2007 - Went to Sons of Italy Annual NELA (National Education Leadership Awards) dinner at the Washington Grand Hyatt Hotel on 10th and H Streets.

Diary Prequel Package, p.155 · original PDF · in context

Clinton was on her way out after having presented Geraldine Ferraro with an Award and we thought that we would not have the opportunity to introduce her to Megan.

Diary Prequel Package, p.155 · original PDF · in context

May 24 - June 17, 2007 - Extremely busy: Sometime since last entry (May 24) I was informed by Jack Marberger (Science Advisor to the POTUS) that I would be receiving the National Medal of Science in a White House ceremony in July.

Diary Prequel Package, p.155 · original PDF · in context

I was one of 8 people who received the award for 2005 (yes 2005 - they are 2 years behind in awarding them).

Diary Prequel Package, p.158 · original PDF · in context

The POTUS laughed and when I went up to the podium to get the medal and shake his hand, he put his arm around me and whispered in my ear "Maybe this guy does not know what you name is, but I certainly do".

Diary Prequel Package, p.158 · original PDF · in context

Word is now out that I will receive the Mary Woodard Lasker Award for Public Service on Sept. 28, 2007 in NYC (see below).

Diary Prequel Package, p.158 · original PDF · in context

Discussed the interesting topic of matching Bob, Luc Montagnier and me for nomination for the Nobel prize for AIDS now that I have won the Lasker Award.

Diary Prequel Package, p.162 · original PDF · in context

"Leadership" Awardees were Ted Kennedy, Sen,.

Diary Prequel Package, p.163 · original PDF · in context

This is contrary to what House Appropriations Chairman Jerry Lewis said at the Appropriations Hearing (see above).

Diary Prequel Package, p.136 · original PDF · in context

Occasion was book signing party for Valeria Plame Wilson to celebrate publishing of her new book "Fair Game" about her outting as a covert CIA agent.

Diary Prequel Package, p.165 · original PDF · in context

After having various agencies present a totality of a program that would cost billions, it was decided that since there really will not be any new money, or if there was, it would be very little, we should focus on the well-circumscribed topic of TB Vaccine research.

Diary Prequel Package, p.166 · original PDF · in context

Terry said that everyone knows in the democratic party that I am most qualified, but that I have "a Bush problem" in that I am too closely associated over the years with the Bush's.

Diary Prequel Package, p.166 · original PDF · in context

I do not necessarily disagree; however, he was terribly gratuitous in saying that "The NIH has lost its way on vaccine research".

Diary Prequel Package, p.168 · original PDF · in context

DSMB stopped study because of "futility" in that the vaccine did not protect against acquisition of infection (not expected to since it is a T cell vaccine) and also did not alter set point of virus.

Diary Prequel Package, p.169 · original PDF · in context

Importantly, for reasons that no one can figure out, vaccinees (not placebos) who had high pre-existing titer of antibody against Ad5, did worse than unvaccinated in acquisition of infection.

Diary Prequel Package, p.169 · original PDF · in context

Was "Top Secret" meeting on anthrax threat with emphasis on drug resistant and even vaccine resistant anthrax.

Diary Prequel Package, p.170 · original PDF · in context

Mar. 25, 2008 - I organized and ran what might be an historic meeting today on the future of HIV Vaccine Research.

Diary Prequel Package, p.172 · original PDF · in context

Ever since the disappointing results from the STEP trial (Merck ad5 prime-boost - see above), there has been increasing pressure within ourselves and in the scientific and certain activist communities to re-evaluate whether we should turn the knob of support more towards basic discovery as opposed to clinical trials of vaccine candidates for an HIV vaccine.

Diary Prequel Package, p.172 · original PDF · in context

They felt that we were wasting money on vaccine trials which they claimed had no basis to predict success based on animal model data.

Diary Prequel Package, p.172 · original PDF · in context

In any event, in a manner similar to how I handled the AIDS activists >20 years ago in that same room (31/7A-24), I listened and suggested that we have HIV Vaccine Summit to discuss the direction of AIDS research.

Diary Prequel Package, p.172 · original PDF · in context

Just a few days ago, a group called AIDS healthcare Foundation stated that we should stop ALL HIV vaccine research and put the money towards proven prevention activities.

Diary Prequel Package, p.172 · original PDF · in context

I focused on a discussion of whether we will ever have a "cure" or a vaccine for HIV.

Diary Prequel Package, p.178 · original PDF · in context

The WH and/or DHHS tried to then get me to agree to be publicly appointed as a "Senior Advisor" to the Acting Director to quell the concerns of the outside people and indicate that a strong, visible, experienced person such as me was "watching the store" even though Kington would be appointed as the official Acting Director.

Diary Prequel Package, p.180 · original PDF · in context

I have some concern at this point that the Vaccine Enterprise in the person of Allan Bernstein is looking for ways to change the direction of HIV vaccine research even though he has been in the field only for months.

Diary Prequel Package, p.181 · original PDF · in context

First and foremost was VP Cheney who expressed his appreciation for "all that I have done for our country" over the years that we had worked together and beyond.

Diary Prequel Package, p.189 · original PDF · in context

The view and ceremony were one of the most special things that I have experienced.

Diary Prequel Package, p.191 · original PDF · in context

Gen Pace is a truly nice man and accepted his award with a moving speech about his parents and grandparents and the men he served with in the marines from the time he was a rifle platoon leader in Viet Nam through Somalia, Iraq, Afghanistan, etc.

Diary Prequel Package, p.194 · original PDF · in context

Recall that there was a "social scandal" when Paul was head of the World Bank and had to leave because it was felt that he was showing favoritism to Shaha who was an employee and was also living with him.

Diary Prequel Package, p.194 · original PDF · in context

Jim Yong Kim, a Harvard medical school professor and former World Health Organization AIDS chief, and was told that she had offered it to Dr.

Diary Prequel Package, p.194 · original PDF · in context

Dybul's departure and the secrecy of the process to replace him has upset some AIDS policy specialists.

Diary Prequel Package, p.194 · original PDF · in context

Dybul was straddling some personal fences too: he was one of the Bush administration's few openly gay officials, a doctor who had treated AIDS patients in San Francisco and Africa, and he had donated to Democratic causes.

Diary Prequel Package, p.194 · original PDF · in context

In separate studies, the Government Accountability Office and the Institute of Medicine both found that the abstinence earmark unnecessarily tied the hands of fund recipients, especially in countries where AIDS was concentrated among drug users and prostitutes. e 7500 range.

Diary Prequel Package, p.194 · original PDF · in context

Dybul defended the teaching of abstinence, especially to young children, because it can be effective among deeply religious rural Africans.

Diary Prequel Package, p.194 · original PDF · in context

Feb. 21, 2009- Had great time receiving the Science and Medicine Award at the 15th Annual Steve Chase Humanitarian Awards Gala at Palm Springs, CA sponsored by the Desert AIDS Project It was an amazing and enjoyable glitzy affair at the Palm Springs Convention Center with Red Carpet arrival similar to the Academy Awards (which actually took place the next day (Sunday) in LA.

Diary Prequel Package, p.197 · original PDF · in context

Other Awardees were Bebe Neuwirth (Broadway star) and Kristin Chenoweth (Broadway Star) for Arts and Activism; Harriet Goldberg won the 100 Women Award; Bill Jones won the Partner for Life Award; Barry Manilow won the Silver Anniversary Community Service Award.

Diary Prequel Package, p.197 · original PDF · in context

Best was Morgan Fairchild who made sure that I was introduced to everyone and also partook in my introduction on stage to receive the award.

Diary Prequel Package, p.197 · original PDF · in context

Today, everyone looks healthy, but the typical protease inhibitor and other drug "facies" were evident with lose of facial fat pads..

Diary Prequel Package, p.199 · original PDF · in context

I was the only government or health official there - a shame since he was such a great man and contributed so much.

Diary Prequel Package, p.199 · original PDF · in context

But, it was not just the official advice that I treasured, it was the phone calls at home at 8:30 PM San Francisco time and 11:30 PM DC time opening with the comment" "I knew that you would be awake and so can you talk?" In a 20 minute call I would learn more about what was going on in the trenches -- and what he thought I should be doing -- than if I had 5 official briefings.

Diary Prequel Package, p.200 · original PDF · in context

This has important implications in the intense planning that is going on in HHS regarding the production and administration of a vaccine.

Diary Prequel Package, p.209 · original PDF · in context

August 9 - 24, 2009 - Our clinical trials with the VETUs on the H1N1 vaccine in adults, elderly for dose (15 versus 30 ug) and number of doses (1 vs 2, 21 days apart) began on Aug. 7 just as I had predicted.

Diary Prequel Package, p.215 · original PDF · in context