Slack / Private Message Drop — page 240

[2020-10-30 12:50:15] [Kristian Andersen] Some of this stuff is actually pretty interesting - but necessarily because of what the paper insinuate. The Huanan market is on Line 2 as well (so is WIV) and where one of these early sequences differ from Hu-1, it is indeed ancestral (as in, the same as RaTG13). I think it's entirely possible these may be some of the very earliest patients and suspected in early December - only later to be sequenced. That Lancet paper with patients dating back to the very beginning of December also shows that China probably knew something was going on early December and not mid-December, which I think is the 'official' story. Not too surprising, but some of these details are pretty interesting. Doesn't really point to lab origins - although the registration dates are a little puzzling and I'm not sure if this particular hospital should raise a flag (it has a weird name, but don't they all - some hospital bound to be first seeing patients...). [2020-10-30 14:43:29] [Eddie Holmes] Here are the sequencing dates that I am pretty bloody certain are correct: [2020-10-30 14:43:34] [Eddie Holmes] •Dec 25: Patient samples sent to (sequencing) Company A •Dec 26: Fragments of SARS-CoV-2 discovered by Company A •Dec 27: Full genome obtained by Company A •Dec 27, 28: Company A report to CDC and hospital in Wuhan •Dec 30: Company B sequence data from another patient •Dec 31: Company B's report (59 reads) "leaked" on social media [2020-10-30 14:43:52] [Eddie Holmes] I think company B is the BGI. [2020-10-30 14:44:24] [Kristian Andersen] Yeah, that's kinda what I thought. There's no question these four runs were registered on 12/10 though - which is kinda peculiar. [2020-10-30 14:45:16] [Kristian Andersen] I thought maybe BGI would have made a bunch of registrations (because I assume they're sequencing from patients frequently), but that wasn't really the case - as far as I can see, only these four ones. [2020-10-30 14:45:59] [Kristian Andersen] E.g., this one: https://www.ebi.ac.uk/biosamples/samples/SAMEA6507890 [2020-10-30 14:48:42] [Kristian Andersen] Interesting list of collaborating institutions there too - I assume Weifeng is probably the person from Shandong. [2020-10-30 14:49:32] [Eddie Holmes] Yes, I can check with Weifeng. I don't understand it, but I can't believe those dates are correct. [2020-10-30 14:50:04] [Kristian Andersen] The dates are correct, I think - I don't think those can be wrong, since they're all recorded by the ENA - not the submitter.