Slack / Private Message Drop — page 185

Tree above - quick ML tree. You'll see close clustering with the consensus genome, but this might be an artifact because non-coverage in the minor genome would just display the consensus genome. Definitely worth looking a little closer. [shared file(s): variants.tsv, variants_pos.pdf] [2020-09-18 18:11:03] [Eddie Holmes] Got it! Sorry, our posts crossed. I'll have a chat to Weifeng. Nice one. Is RmYN01 closer than ZC45? I'm trying to get more bat ronas as we speak (through a very unusual source). More later. [2020-09-19 08:59:36] [Robert Garry] ```ppttStrfrraTSgvs``` Don't want to distract from this important work and I think @Andrew Rambaut has already figured most of this out, but there is a relevant story about furin cleavage sites in MERS CoV. This sequence is from HKU5, which has a very MERS-like spike [ https://pubmed.ncbi.nlm.nih.gov/23720729/ ] and a somewhat better FCS than the minimal one in MERS-CoV. The capitalized STS are predicted O-glycans. Maybe these are used maybe not, but coincidences keep popping up {HKU1, OC43, MHC etc]. It's another data point that I believe shows that the furin site in SARS2 could evolve naturally. At the end of the day [thanks to this good work K and E] besides the wild thrashing around the "unusual" FCS is about all the Yans and Chans of the world are going to have left. [2020-09-19 09:11:01] [Robert Garry] I think you should put this up in a peer-reviewed journal ASAP. Maybe it's my mean streak, maybe it's just that I think that Daszak is going to screw it up or maybe I think the RBG September surprise has shook up the Presidential race, but the "*IT ESCAPED FROM WIV*" crowd is empowered not depowered at the moment - science literally be damned. [2020-09-19 09:17:09] [Kristian Andersen] Nah, I got more important papers to attend to - most importantly, one from NOLA :wink:. I'll put a summary up on Virological later today though - just so one can point to it. [2020-09-19 09:28:05] [Robert Garry] OK that should do it - next best thing. It will probably elicit more "Running Dog" commentary on the twitter. Maybe a good thing - you can add to your montage. Nature should give Batwoman a chance to respond to her accusers http s://www.minervanett.no/alina-chan-coronavirus-covid19/contradicting-statements-cast-doubts-on-chinese-raw-data/ 364540 Nothing nefarious there. And yeah - Mardi Gras manuscript! [2020-09-19 16:02:24] [Eddie Holmes] Great job Kristian. Pretty amazing/ridiculous/depressing that we are still debating data that was all published by March. [2020-09-19 19:39:50] [Kristian Andersen] Alright, all assembled - everything checks out. What a huge fucking surprise.... https://virological.org/t/on-the-veracity-of-ratg13/551/9 [2020-09-19 20:19:28] [Eddie Holmes] Oh what a surprise (and what a waste of time). I enjoyed Frankie's poll. He's gradually loosing his mind. [2020-09-19 20:50:51] [Kristian Andersen]