Chat message

Slack / Private Message Drop, p.1100 [SLACK_001314] · slack_pm:msg:11466

Date: 2022-03-25 16:54
Type: chat message · slack
recipient: Kristian G. Andersen, Edward C. Holmes, Andrew Rambaut
speaker: Robert F. Garry
Topics: Intelligence community assessments

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https://virological.org/t/spike-protein-mutations-in-novel-sars-cov-2-variants-of-concern-commonly-occur-in-or-near-indels/605 I'm wondering if we shouldn't update the INDEL virological post with BA.1 and BA.2. The association ofthe Omicron mutations in BA.1 and BA.2 with indels is *even more pronounced*. Started to draft an alignment, but this should also included Alpha, Beta and Gamma. [shared file(s): image.png]

Links shared

preprint https://virological.org/t/spike-protein-mutations-in-novel-sars-cov-2-variants-of-concern-commonly-occur-in-or-near-indels/605

Extracted statements

Rule-extracted, not adjudicated. The grade says what may be done with each one; read the document above before relying on any of them.

Statement	Grade	Attribution	Stance
The association ofthe Omicron mutations in BA.1 and BA.2 with indels is even more pronounced.	own voice, substantive	speaker_own	asserts

Statement

Grade

Attribution

Stance

The association ofthe Omicron mutations in BA.1 and BA.2 with indels is *even more pronounced*.

own voice, substantive

speaker_own

asserts

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2022-03-25 16:54 Robert F. Garry

https://virological.org/t/spike-protein-mutations-in-novel-sars-cov-2-variants-of-concern-commonly-occur-in-or-near-indels/605 I'm wondering if we shouldn't update the INDEL virological post with BA.1 and BA.2. The association ofthe Omicron mutations in BA.1 and BA.2 with indels is *even more pronounced*. Started to draft an alignment, but this should also included Alpha, Beta and Gamma. [shared file(s): image.png]
2022-03-25 16:57 Robert F. Garry open

Also as @Kristian Andersen noted something up with the glycosylation sites. BA.2 loses its first N-linked site (whichis unlike any other variant of concern AFAIK), but interestingly to me BA.2 picks up a predicted O-linked glycan at349 that is also present in the BANAL viruses.

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