Chat message

Slack / Private Message Drop, p.1003 [SLACK_001217] · slack_pm:msg:10466

Recipients on this medium are inferred from channel membership, not per-message addressing.

for sc1 the ones I have my eye on are N 29, 73 and maybe 227

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2021-09-21 16:25 Robert F. Garry open

SC1 coming
2021-09-21 16:37 Edward C. Holmes open

I'd love to know what a 'human specific furin cleavage site' is.
2021-09-21 16:48 Kristian G. Andersen open

It's not "PRRAR", that's for sure.
2021-09-21 16:48 Kristian G. Andersen open

@Robert Garry - I'm using NetNGlyc and since N-linked glycans are easy to predict I think I have what I need
2021-09-21 16:51 Robert F. Garry

for sc1 the ones I have my eye on are N 29, 73 and maybe 227
2021-09-21 16:52 Robert F. Garry open

variable with close bat viruses like KY417150
2021-09-21 17:14 Kristian G. Andersen open

@Robert Garry what are the key N-linked sites for the DC-SIGN/L-SIGN stuff? I have my eye focused on residue 370 in SC2 (357 in SC1) since that is a FULLY conserved N-linked glycan across _all_ sarbecos, _except_ in SC2 because residue 372 changes from a fully conserved T to an A (via a single A>G transition in the first codon position). In the RBD there are three N-linked glycans in SC2/BANAL, so two are conserved, one is not.
2021-09-21 17:19 Kristian G. Andersen open

We have _some_ information about what this particular residue does in SC2: https://pubmed.ncbi.nlm.nih.gov/34289344/