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Slack / Private Message Drop, p.857 [SLACK_001071] · slack_pm:msg:08916

Date: 2021-05-23 11:38
Type: chat message · slack
mentioned: Kristian G. Andersen
recipient: Kristian G. Andersen, Edward C. Holmes, Andrew Rambaut
speaker: Robert F. Garry

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For the virus glycoprotein nerdboys note that RaTG15 and RsYN04 have CXK insert at indel 4a. Both viruses have an added cysteine 5 or 4 amino acids towards the N-term. So, these viruses either have an extra tight cysteine loopin the N-terminal domain or as discussed in channel above have a metal binding domain in the N-terminus. One of@Kristian Andersen long covid patients has an added dicysteine in the N-terminus. Also W152C in B.1.427/429 isan unpaired cysteine which is just not hanging in space so might work with H69, H146 and H245 to bind a metal ion.Cryo EM guys/girls get busy.

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2021-05-23 11:36 Robert F. Garry open

Putting RaTG15 plus some of the other new viruses into the Holmes2021 alignment. Some of these could potentiallybe in the Evidence Doc. RpYN06 (@Eddie Holmes new _Cell_ paper) and PCR31 lay to rest Alina's slander that GDpangolin is fake. See similarity in indels 1,2,3 and 5. Also probably makes sense to update the virological post. [shared file(s): image.png]
2021-05-23 11:38 Robert F. Garry

For the virus glycoprotein nerdboys note that RaTG15 and RsYN04 have CXK insert at indel 4a. Both viruses have an added cysteine 5 or 4 amino acids towards the N-term. So, these viruses either have an extra tight cysteine loopin the N-terminal domain or as discussed in channel above have a metal binding domain in the N-terminus. One of@Kristian Andersen long covid patients has an added dicysteine in the N-terminus. Also W152C in B.1.427/429 isan unpaired cysteine which is just not hanging in space so might work with H69, H146 and H245 to bind a metal ion.Cryo EM guys/girls get busy.
2021-05-23 11:44 Robert F. Garry open

"Big names, titles don't always = truth." I believe that Ms. Young is talking about us gentlemen. Truly pisses me off. [shared file(s): image.png]
2021-05-23 11:47 Robert F. Garry open

She and Alina seems to be taking the victory lap together.
2021-05-23 11:48 Robert F. Garry open

Note - the align - still a WIP...
2021-05-23 11:54 Kristian G. Andersen open

What's funny here - I can certainly agree that "big names, titles don't always = truth", but referring to the Bloomshitters and not actually us. The truth will ultimately prevail. Just had a meeting with Fauci and his team this morning - they get it and deeply appreciate what we're doing, sowe'll keep dancing...

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