Chat message

Slack / Private Message Drop, p.857 [SLACK_001071] · slack_pm:msg:08915

Date: 2021-05-23 11:36
Type: chat message · slack
mentioned: Edward C. Holmes
recipient: Kristian G. Andersen, Edward C. Holmes, Andrew Rambaut
speaker: Robert F. Garry
Topics: Natural origin / zoonotic spillover

Recipients on this medium are inferred from channel membership, not per-message addressing.

Putting RaTG15 plus some of the other new viruses into the Holmes2021 alignment. Some of these could potentiallybe in the Evidence Doc. RpYN06 (@Eddie Holmes new _Cell_ paper) and PCR31 lay to rest Alina's slander that GDpangolin is fake. See similarity in indels 1,2,3 and 5. Also probably makes sense to update the virological post. [shared file(s): image.png]

Extracted statements

Rule-extracted, not adjudicated. The grade says what may be done with each one; read the document above before relying on any of them.

Statement	Grade	Attribution	Stance
RpYN06 (@Eddie Holmes new _Cell_ paper) and PCR31 lay to rest Alina's slander that GDpangolin is fake.	own voice, substantive	speaker_own	asserts

Statement

Grade

Attribution

Stance

RpYN06 (@Eddie Holmes new _Cell_ paper) and PCR31 lay to rest Alina's slander that GDpangolin is fake.

own voice, substantive

speaker_own

asserts

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2021-05-23 11:36 Robert F. Garry

Putting RaTG15 plus some of the other new viruses into the Holmes2021 alignment. Some of these could potentiallybe in the Evidence Doc. RpYN06 (@Eddie Holmes new _Cell_ paper) and PCR31 lay to rest Alina's slander that GDpangolin is fake. See similarity in indels 1,2,3 and 5. Also probably makes sense to update the virological post. [shared file(s): image.png]
2021-05-23 11:38 Robert F. Garry open

For the virus glycoprotein nerdboys note that RaTG15 and RsYN04 have CXK insert at indel 4a. Both viruses have an added cysteine 5 or 4 amino acids towards the N-term. So, these viruses either have an extra tight cysteine loopin the N-terminal domain or as discussed in channel above have a metal binding domain in the N-terminus. One of@Kristian Andersen long covid patients has an added dicysteine in the N-terminus. Also W152C in B.1.427/429 isan unpaired cysteine which is just not hanging in space so might work with H69, H146 and H245 to bind a metal ion.Cryo EM guys/girls get busy.
2021-05-23 11:44 Robert F. Garry open

"Big names, titles don't always = truth." I believe that Ms. Young is talking about us gentlemen. Truly pisses me off. [shared file(s): image.png]
2021-05-23 11:47 Robert F. Garry open

She and Alina seems to be taking the victory lap together.
2021-05-23 11:48 Robert F. Garry open

Note - the align - still a WIP...

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