Chat message

Slack / Private Message Drop, p.841 [SLACK_001055] · slack_pm:msg:08753

Date: 2021-05-19 14:48
Type: chat message · slack
recipient: Kristian G. Andersen, Robert F. Garry, Andrew Rambaut
speaker: Edward C. Holmes
Topics: Furin cleavage site and molecular features Wuhan Institute of Virology collaboration

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@Eddie Holmes Yes, no one would engineer that RBD so it has to be natural. And if that's natural so is the FCS. That then must mean they had a virus very close to SC2 at WIV. But if had worked on and sequenced such a virus -which would have been so interesting - why is there no record of it in their data or a paper? If both such a virus and RaTG13 had come out of a mine in Yunnan would they have only published RaTG13?

Extracted statements

Rule-extracted, not adjudicated. The grade says what may be done with each one; read the document above before relying on any of them.

Statement	Grade	Attribution	Stance
@Eddie Holmes Yes, no one would engineer that RBD so it has to be natural.	own voice, substantive	speaker_own	asserts
That then must mean they had a virus very close to SC2 at WIV.	own voice, substantive	speaker_own	asserts

Statement

Grade

Attribution

Stance

@Eddie Holmes Yes, no one would engineer that RBD so it has to be natural.

own voice, substantive

speaker_own

asserts

That then must mean they had a virus very close to SC2 at WIV.

own voice, substantive

speaker_own

asserts

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2021-05-19 14:37 Edward C. Holmes open

@Eddie Holmes And shows why the conspiracy theorists are so keen to attack the pangolin data
2021-05-19 14:38 Kristian G. Andersen open

@Eddie Holmes It's a really inconvenient piece of evidence. It's the one thing that solidified my belief.
2021-05-19 14:38 Edward C. Holmes open

@Eddie Holmes Me too
2021-05-19 14:38 Robert F. Garry open

@Eddie Holmes The large city thing that Eddie identified is important to counter the WIV is in Wuhan.
2021-05-19 14:48 Edward C. Holmes

@Eddie Holmes Yes, no one would engineer that RBD so it has to be natural. And if that's natural so is the FCS. That then must mean they had a virus very close to SC2 at WIV. But if had worked on and sequenced such a virus -which would have been so interesting - why is there no record of it in their data or a paper? If both such a virus and RaTG13 had come out of a mine in Yunnan would they have only published RaTG13?
2021-05-19 14:53 Andrew Rambaut open

Look forward to it! It was an interesting experience getting 3 competing groups to all work together and just publish one good paper!
2021-05-19 15:00 Robert F. Garry open

Well done - if you don't mind I'll mention that very thing [in a nice way].
2021-05-19 15:09 Robert F. Garry open

@Eddie Holmes SC1 in Foshan (7.2M ppl) farmers, market vendors, and chefs). Agree that Eddie HKU1 emerging in Shenzhen (13M ppl) is instructive.
2021-05-19 15:17 Robert F. Garry open

@Eddie Holmes • Intermediate hosts also instructive. Intermediate host of of HKU1 and HL63 like SC2 is not known. MERS-CoV IMO is the only human CoV in which the intermediate host the camel a highly domesticated animal iswell established. For the other human CoVs the intermediate hosts IMO can each fall into the highly suspected category, but not proven. SC1 civets obviously can infected in wildlife trade, but could be other spillover hosts and the reservoir may be another animal. OC43 the same intermediate host is likely a bovine, obviously a highlydomesticated animals but which bovine? 299E intermediate might be an alpaca (PMID: 26378164).

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