A single line often inverts meaning once you see what it
answers, so neighbouring messages are always shown.
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Look forward to it! It was an interesting experience getting 3 competing groups to all work together and just publish one good paper!
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Well done - if you don't mind I'll mention that very thing [in a nice way].
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@Eddie Holmes SC1 in Foshan (7.2M ppl) farmers, market vendors, and chefs). Agree that Eddie HKU1 emerging in Shenzhen (13M ppl) is instructive.
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@Eddie Holmes • Intermediate hosts also instructive. Intermediate host of of HKU1 and HL63 like SC2 is not known. MERS-CoV IMO is the only human CoV in which the intermediate host the camel a highly domesticated animal iswell established. For the other human CoVs the intermediate hosts IMO can each fall into the highly suspected category, but not proven. SC1 civets obviously can infected in wildlife trade, but could be other spillover hosts and the reservoir may be another animal. OC43 the same intermediate host is likely a bovine, obviously a highlydomesticated animals but which bovine? 299E intermediate might be an alpaca (PMID: 26378164).
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2021-05-19 15:23
Kristian G. Andersen
@Eddie Holmes I don't really think camels can be considered an "intermediate" host for MERS - seems more to me that MERS is causing an epizootic in camels, so it's pretty much a camel virus by now.
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@Eddie Holmes Spillovers are rare. Domesticated animals a key at least for Covs- probably by serving to amplify the virus in close quarters. Pigs get other CoVs - PEDV and SADS-CoV - that are likely direct spillovers from bats. Something about the big cities makes the spillover stick. Could be same thing this time humans living in closequarters able to initiate transmission chains. This happened in West Africa Ebola. The reason why no very large Ebola outbreaks in Middle Africa is population density (we might have a paper on that).
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@Eddie Holmes Good point - but that makes the distinction btwn MERS and the rest of the human CoVs all that stronger.
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@Eddie Holmes So, question: is SC1 an epizootic in civets? Hard to argue there's definite proof of that but maybe i'm missing something.
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External Sender. Be aware of links, attachments and requests. Thanks, Bob. Nice to be in touch and I hope all's well. Cheers, Mike __________________ ____ From: Garry, Robert F > Sent: Wednesday, May 19, 2021 2:19 PM To: Bloom PhD, Jesse D; David A Relman; Worobey, Michael - (worobey) Subject: [EXT]Re: Technical Comment External Email That's correct I think. My understanding is that Science will decide whether or not to send for review, then ask you for a comment. Of course, based on the review they may or may not "publish." In the case of a Technical Comment publish means on-line only. Apparently, they may put the 60-word abstract in the paper journal (which perhaps a few people still look at). Cheers, Bob G. SLACK_001057 From: "Bloom PhD, Jesse O, a &<': Date: Wednesday, May 19,2 at 4: I>, David A Reiman i &01:, "Worobey, Michael - gt: (worobey)" Subject: Re: Technical Commen External Sender. Be aware of links, attachments and requests. Hi Bob, I just wanted to follow up, and am also cc-ing Mike Worobey as he is interested in this topic. Thanks again for looping us in about your comment piece. It sounds like we don't have to draft a full formal response now. But if Science considers your comment then we'd be happy to draft a response. If they don't (I'm not sure how often they published letters about letters?), if you submit your comment as an e-letter online then we would be happyto submit a response as an e-letter too. Anyway, really appreciate you keeping us informed about this, and we agree it's important to try to figure out ways todiscuss these topics in measured academic formats exactly as you are trying to initiate here! --Jesse