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Slack / Private Message Drop, p.700 [SLACK_000914] · slack_pm:msg:07347

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Probably good to keep in mind that GX pango is very similar to SC2 in much of the NTD except IR2 where some of the magic may be happening.

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2021-04-13 14:55 Andrew Rambaut open

I think you could argue that the pangolin is actually less likely to be the intermediate for SC2. The original Wuhan was more bat like in its NTD and it took all the way to B.1.1.7 before it hit its stride (you also see the same mutationsin chronic infections - so again that might explain the fitness jump to get there).
2021-04-13 14:56 Andrew Rambaut open

There could be other NTD point mutations that provide a similar effect.
2021-04-13 15:01 Edward C. Holmes open

I think that's what I was I trying to say - that the intermediate host is a different species....but has a virus with acomplex recombinant history, like SIVcpz.
2021-04-13 15:04 Edward C. Holmes open

Or that WIV weren't finished in their engineering job
2021-04-13 15:09 Robert F. Garry

Probably good to keep in mind that GX pango is very similar to SC2 in much of the NTD except IR2 where some of the magic may be happening.
2021-04-13 15:10 Edward C. Holmes open

Good point
2021-04-13 15:29 Andrew Rambaut open

I think clearly WIV were really shit at creating SC2
2021-04-13 15:30 Andrew Rambaut open

GX pango still not nearly as similar as RaTG13: [shared file(s): image.png]
2021-04-13 15:32 Andrew Rambaut open

Just noticed that dip in early ORF1a - don't know why I didn't notice that before.