A single line often inverts meaning once you see what it
answers, so neighbouring messages are always shown.
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Ah, interesting - need to dig a little further then (we can now do pango lineage + mutation on outbreak.info, so that's pretty nifty). If this is the one with, especially, eek, then that's interesting - a lot of standing immunity in large parts ofNYC.
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That's a really good point about all the pre-existing immunity in NYC. E484K doing double duty - ACE2 binding plusa neutralizing epitope. S477N likely the same/overlapping epitope, but NO interaction with ACE2 at least directly. [shared file(s): image.png]
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@Andrew Rambaut Q957R is interesting - Q957 probably forms a salt bridge with K304. Put another positive charge there make clash and likely "loosens up" the monomer more than a bit. Like Eddies corridor analogy though - variants finding their way down to a common path,
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Yeah, B.1.526 with eek is definitely rising in New York. This might be real. https://outbreak.info/situation-reports?country=United%20States&division=California[...]1.526&muts=S%3 AE484K&selected=New%20York&selectedType=division
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2021-02-24 09:27
Robert F. Garry
Speaking of the WSJ - they just requested an interview to discuss our Virological post.
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It is weird the V701A reverting in the S477N lineage - maybe the tree is wrong
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HMMMM - that is interesting.
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Oh... We have identified a MAJOR issue with Illumina's consensus caller - it's calling reference calls if there are _any_ mismatching reads at a variant site. That might be why
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If this is from NYC, it's possible they used Illumina's DRAGEN pipeline