Chat message

Slack / Private Message Drop, p.545 [SLACK_000759] · slack_pm:msg:05677

Date: 2021-02-24 08:26
Type: chat message · slack
recipient: Robert F. Garry, Edward C. Holmes, Andrew Rambaut
speaker: Kristian G. Andersen
Topics: Intelligence community assessments

Recipients on this medium are inferred from channel membership, not per-message addressing.

Ah, interesting - need to dig a little further then (we can now do pango lineage + mutation on outbreak.info, so that's pretty nifty). If this is the one with, especially, eek, then that's interesting - a lot of standing immunity in large parts ofNYC.

Extracted statements

Rule-extracted, not adjudicated. The grade says what may be done with each one; read the document above before relying on any of them.

Statement	Grade	Attribution	Stance
If this is the one with, especially, eek, then that's interesting - a lot of standing immunity in large parts ofNYC.	quoted / not their view	hypothetical conditional framing	asserts

Statement

Grade

Attribution

Stance

If this is the one with, especially, eek, then that's interesting - a lot of standing immunity in large parts ofNYC.

quoted / not their view

hypothetical conditional framing

asserts

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2021-02-24 07:41 Kristian G. Andersen open

Hah, this is sooooo terrible. I'm pretty sure that Pompy looked up "Biosafety Level", thought, "That's some scary shit- let's blame China", and grabbed the keyboard.US politicians (and intelligence) actually used to be widely respected in the world. Boy, has that gone downhill.
2021-02-24 07:44 Kristian G. Andersen open

We now have an "NYC" variant... Sigh. Any concerns about any of these mutations - especially the ORF1s? [shared file(s): Screen Shot 2021-02-24 at 7.38.07 AM.png]
2021-02-24 07:45 Kristian G. Andersen open

Here's the report on it - rising in NYC (yes, of course there's a preprint...) https://outbreak.info/situation-reports?country=United%20States&division=California[...]20York&pango=B .1.526&selected=New%20York&selectedType=division
2021-02-24 08:11 Andrew Rambaut open

There are 2 subclades of B.1.526 - one has E484K, the other S477N. https://github.com/cov-lineages/pango-designation/issues/6
2021-02-24 08:26 Kristian G. Andersen

Ah, interesting - need to dig a little further then (we can now do pango lineage + mutation on outbreak.info, so that's pretty nifty). If this is the one with, especially, eek, then that's interesting - a lot of standing immunity in large parts ofNYC.
2021-02-24 08:51 Robert F. Garry open

That's a really good point about all the pre-existing immunity in NYC. E484K doing double duty - ACE2 binding plusa neutralizing epitope. S477N likely the same/overlapping epitope, but NO interaction with ACE2 at least directly. [shared file(s): image.png]
2021-02-24 09:02 Robert F. Garry open

@Andrew Rambaut Q957R is interesting - Q957 probably forms a salt bridge with K304. Put another positive charge there make clash and likely "loosens up" the monomer more than a bit. Like Eddies corridor analogy though - variants finding their way down to a common path,
2021-02-24 09:22 Kristian G. Andersen open

Yeah, B.1.526 with eek is definitely rising in New York. This might be real. https://outbreak.info/situation-reports?country=United%20States&division=California[...]1.526&muts=S%3 AE484K&selected=New%20York&selectedType=division
2021-02-24 09:27 Robert F. Garry open

Speaking of the WSJ - they just requested an interview to discuss our Virological post.

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