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Slack / Private Message Drop, p.537 [SLACK_000751] · slack_pm:msg:05591

Page text: p.537 · original PDF

Date
2021-02-21 15:43
Type
chat message · slack
recipient
Kristian G. Andersen, Robert F. Garry, Andrew Rambaut
speaker
Edward C. Holmes

Recipients on this medium are inferred from channel membership, not per-message addressing.

But they do then do experimental assays to confirm these computational results. I can't judge how good these are. The bottom-line that there has been a continual adaptive process.

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

  1. 2021-02-21 15:24 Edward C. Holmes open
    Are there *proportionately* more chronic infections? Do we know their overall frequency?
  2. 2021-02-21 15:27 Edward C. Holmes open
    Definitely needs to be set out here.
  3. 2021-02-21 15:35 Edward C. Holmes open
    The Chan/Petrosky analysis was that dn/ds suggested that there was NO adaptation to humans. This shows otherwise. We know that this mutation is fixed in all the human samples studied to date, but we don't know about any chains of transmission that died out.
  4. 2021-02-21 15:43 Andrew Rambaut open
    Hmm. Not sure about this paper - they are using software for detecting genomic selective sweeps using LD, I think.
  5. 2021-02-21 15:43 Edward C. Holmes
    But they do then do experimental assays to confirm these computational results. I can't judge how good these are. The bottom-line that there has been a continual adaptive process.
  6. 2021-02-21 15:49 Kristian G. Andersen open
    Yeah, the sweep analyses are shit - can't do that in viral genomes, only sexually reproducing organisms. That said, they DID come across a very very interesting mutation (by chance?) and the experimental data is good
  7. 2021-02-21 15:53 Edward C. Holmes open
    Yes, it's the experimental data that is interesting.
  8. 2021-02-21 15:59 Edward C. Holmes open
    In other news: https://peterdaszak.com/
  9. 2021-02-21 16:01 Edward C. Holmes open
    @Kristian Andersen You're included for your 'fairy tales'. Someone has put a lot of effort into this shit.

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