Slack / Private Message Drop — page 537

[Eddie Holmes] [thread - ID: 2021-02-20 10:31:01] Definitely needs to be set out here. [2021-02-21 15:35:40] [Eddie Holmes] [thread - ID: 2021-02-21 15:18:13] The Chan/Petrosky analysis was that dn/ds suggested that there was NO adaptation to humans. This shows otherwise. We know that this mutation is fixed in all the human samples studied to date, but we don't know about any chains of transmission that died out. [2021-02-21 15:43:01] [Andrew Rambaut] Hmm. Not sure about this paper - they are using software for detecting genomic selective sweeps using LD, I think. [2021-02-21 15:43:48] [Eddie Holmes] But they do then do experimental assays to confirm these computational results. I can't judge how good these are. The bottom-line that there has been a continual adaptive process. [2021-02-21 15:49:38] [Kristian Andersen] Yeah, the sweep analyses are shit - can't do that in viral genomes, only sexually reproducing organisms. That said, they DID come across a very very interesting mutation (by chance?) and the experimental data is good [2021-02-21 15:53:14] [Eddie Holmes] Yes, it's the experimental data that is interesting. [2021-02-21 15:59:02] [Eddie Holmes] In other news: https://peterdaszak.com/ [2021-02-21 16:01:55] [Eddie Holmes] @Kristian Andersen You're included for your 'fairy tales'. Someone has put a lot of effort into this shit. [2021-02-21 16:13:47] [Kristian Andersen] Well, they got my last name wrong so they can't be that clever... Unbelievable how much time some people have on their hands. [shared file(s): Screen Shot 2021-02-21 at 4.13.10 PM.png] [2021-02-21 16:14:30] [Kristian Andersen] "PETER DASZAK MEMORIAL RESEARCH INSTITUTE". That's pretty good - I gotta admit. [2021-02-21 16:16:37] [Kristian Andersen] ... made with Microsoft FrontPage - oldskool. [2021-02-21 16:18:13] [Eddie Holmes]