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Slack / Private Message Drop, pp.528-529 [SLACK_000742] · slack_pm:msg:05511

Date: 2021-02-20 07:14
Type: chat message · slack
recipient: Kristian G. Andersen, Robert F. Garry, Edward C. Holmes
speaker: Andrew Rambaut

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Full complement is: Spike: F157L, V367F, Q613H, P681R, R102I N: Q39R, S202N NS8: L84S, E92K NSP4: T495I NSP6: L98F, M183I, M86I NSP12: Y346H Could the NSP6 have similar effects to the deletion?

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2021-02-20 07:11 Andrew Rambaut open

Interesting though is A.23.1 with Doug's neighbour Qeith. It has NSP12 Y346H - related?
2021-02-20 07:12 Andrew Rambaut open

(also 681R of course)
2021-02-20 07:14 Andrew Rambaut

Full complement is: Spike: F157L, V367F, Q613H, P681R, R102I N: Q39R, S202N NS8: L84S, E92K NSP4: T495I NSP6: L98F, M183I, M86I NSP12: Y346H Could the NSP6 have similar effects to the deletion?
2021-02-20 07:23 Andrew Rambaut open

Much of this is discussed in https://www.medrxiv.org/content/10.1101/2021.02.08.21251393v1.full.pdf but I don't think we mentioned the RdRp mutation because P323L has never really been talked about yet.
2021-02-20 07:33 Robert F. Garry open

Y346H -not directly in the groove itself *but right in line with the P323*. So putting that charged Histidine in is goingto disrupt the bonding underlaying the channel and have a very similar effect to PhiL. [shared file(s): image.png]
2021-02-20 07:36 Andrew Rambaut open

Bingo.
2021-02-20 07:39 Andrew Rambaut open

So we have a common set of functional sites/effects for all the new variants: An RdRp mutation, an nsp6 modification, spike 613/614, some NTD mutations/deletions and some RBD mutations.

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