Chat message

Slack / Private Message Drop, p.528 [SLACK_000742] · slack_pm:msg:05509

Recipients on this medium are inferred from channel membership, not per-message addressing.

Interesting though is A.23.1 with Doug's neighbour Qeith. It has NSP12 Y346H - related?

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2021-02-20 07:11 Andrew Rambaut

Interesting though is A.23.1 with Doug's neighbour Qeith. It has NSP12 Y346H - related?
2021-02-20 07:12 Andrew Rambaut open

(also 681R of course)
2021-02-20 07:14 Andrew Rambaut open

Full complement is: Spike: F157L, V367F, Q613H, P681R, R102I N: Q39R, S202N NS8: L84S, E92K NSP4: T495I NSP6: L98F, M183I, M86I NSP12: Y346H Could the NSP6 have similar effects to the deletion?
2021-02-20 07:23 Andrew Rambaut open

Much of this is discussed in https://www.medrxiv.org/content/10.1101/2021.02.08.21251393v1.full.pdf but I don't think we mentioned the RdRp mutation because P323L has never really been talked about yet.
2021-02-20 07:33 Robert F. Garry open

Y346H -not directly in the groove itself *but right in line with the P323*. So putting that charged Histidine in is goingto disrupt the bonding underlaying the channel and have a very similar effect to PhiL. [shared file(s): image.png]