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Slack / Private Message Drop, p.456 [SLACK_000670] · slack_pm:msg:04732

Page text: p.456 · original PDF

Date: 2021-01-26 17:27
Type: chat message · slack
mentioned: Kristian G. Andersen
recipient: Kristian G. Andersen, Edward C. Holmes, Andrew Rambaut
speaker: Robert F. Garry

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@Kristian Andersen Of course, I'll send when I get back to the office computer.

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2021-01-26 17:22 Kristian G. Andersen open

How people can look at this data and conclude that "it'll be totally fine for vaccines - all good news", I simply don't understand. Either it's delusional or it's because we have now (yet again) turned to wishful thinking. There is little doubt in my mind we'll have to update the vaccine. Will B.1.351 kill them completely? Very likely not -however, there's going to be a hard hit to the efficacy because of this.
2021-01-26 17:22 Edward C. Holmes open

I thought not...
2021-01-26 17:23 Edward C. Holmes open

Fucker as you say...
2021-01-26 17:24 Kristian G. Andersen open

The Moderna paper yesterday (which looks more promising) they literally took the serum at the very peak (a week after the booster) so the data would look better. In this paper they wait a few weeks and see a more worrisome effect - similar to the observations from RSA. In any case - it sounds like Moderna is already working on an updated design, so that's the right thing to do - I just hope that work gets fast-tracked.
2021-01-26 17:27 Robert F. Garry

@Kristian Andersen Of course, I'll send when I get back to the office computer.
2021-01-26 17:36 Edward C. Holmes open

Indeed! Sounds like an update is needed ASAP.
2021-01-26 17:44 Kristian G. Andersen open

I don't necessarily think it needs to get into people ASAP, but the whole process absolutely needs to be started ASAP - it's not a simple "six week and we're done" process. Better have this ready to go over the summer.
2021-01-26 17:46 Edward C. Holmes open

Totally agree.
2021-01-26 18:04 Kristian G. Andersen open

Just looking at that CamboBat paper - very interesting. One thing they miss - that mismatch in the key RBD residue where CamboBat has "P" and the PangoCoV and SC2 have "F" (and SC1 / RmYN02 have "L") the "pre"-SARS CoVs from e.g., civets ALSO have "P". Pretty interesting. [shared file(s): Screen Shot 2021-01-26 at 5.59.43PM.png, Screen Shot 2021-01-26 at 6.03.31 PM.png]

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