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Slack / Private Message Drop, pp.455-456 [SLACK_000669] · slack_pm:msg:04727

Page text: p.455, p.456 · original PDF

Date
2021-01-26 17:20
Type
chat message · slack
recipient
Robert F. Garry, Edward C. Holmes, Andrew Rambaut
speaker
Kristian G. Andersen

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Here's the paper from David Ho - B.1.351 not looking good: https://www.biorxiv.org/content/10.1101/2021.01.25.428137v2.full.pdf

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  1. 2021-01-26 16:26 Robert F. Garry open
    Alignment including Thai Bat CoV and Cambodian Bat CoV. Take homes: Thai Bat spike and RmYN02 spike are nearly identical, including at the S1/S2 cleavage site. Cambobatcov RBD is very similar to PangoGD RBD and SARS-CoV-2 RBD. 5/6 pf the PO1 key residues. Cambobatcov also has the Furin landing site QTQTN, like RaTG13, GD Pango and SARS-CoV-2, that is often deleted on extended cell passage. [shared file(s): image.png]
  2. 2021-01-26 16:38 Kristian G. Andersen open
    Nice! Bob, can you please share the actual alignment? Would like to try and merge it with what I have.
  3. 2021-01-26 16:41 Edward C. Holmes open
    Great work Bob! Hoping to get the Yunnan bat virus sequences soon.
  4. 2021-01-26 17:20 Kristian G. Andersen
    Here's the paper from David Ho - B.1.351 not looking good: https://www.biorxiv.org/content/10.1101/2021.01.25.428137v2.full.pdf
  5. 2021-01-26 17:22 Kristian G. Andersen open
    How people can look at this data and conclude that "it'll be totally fine for vaccines - all good news", I simply don't understand. Either it's delusional or it's because we have now (yet again) turned to wishful thinking. There is little doubt in my mind we'll have to update the vaccine. Will B.1.351 kill them completely? Very likely not -however, there's going to be a hard hit to the efficacy because of this.
  6. 2021-01-26 17:22 Edward C. Holmes open
    I thought not...
  7. 2021-01-26 17:23 Edward C. Holmes open
    Fucker as you say...
  8. 2021-01-26 17:24 Kristian G. Andersen open
    The Moderna paper yesterday (which looks more promising) they literally took the serum at the very peak (a week after the booster) so the data would look better. In this paper they wait a few weeks and see a more worrisome effect - similar to the observations from RSA. In any case - it sounds like Moderna is already working on an updated design, so that's the right thing to do - I just hope that work gets fast-tracked.

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