Slack / Private Message Drop — page 455

[2021-01-26 10:47:02] [Robert Garry] Yuri has moved up to clustal W - however the Thai bat viruses are interesting [shared file(s): image.png] [2021-01-26 10:54:16] [Kristian Andersen] Their obsession with the FCS will backfire - we'll get viruses with more similar insertions and then their main argument becomes completely mute. Of course, they'll just move the goal post. [2021-01-26 10:57:38] [Robert Garry] RmYN02 like cleavage site [shared file(s): image.png] [2021-01-26 11:11:12] [Robert Garry] MW251308 this is Linfa and apparently he has some Thai pangos as well..... [shared file(s): image.png] [2021-01-26 12:16:03] [Kristian Andersen] Dang. https://www.medrxiv.org/content/10.1101/2021.01.21.21249203v1 [2021-01-26 12:35:50] [Eddie Holmes] Very interesting to see all these new animal viruses. I've just approved the Cambodian bat one for bioRxiv. [2021-01-26 12:37:51] [Eddie Holmes] Interesting paper on the new variants by David Ho as well. [2021-01-26 12:51:34] [Kristian Andersen] URL? [2021-01-26 13:50:00] [Eddie Holmes] The Cambodian paper is now online [2021-01-26 16:26:04] [Robert Garry] Alignment including Thai Bat CoV and Cambodian Bat CoV. Take homes: Thai Bat spike and RmYN02 spike are nearly identical, including at the S1/S2 cleavage site. Cambobatcov RBD is very similar to PangoGD RBD and SARS-CoV-2 RBD. 5/6 pf the PO1 key residues. Cambobatcov also has the Furin landing site QTQTN, like RaTG13, GD Pango and SARS-CoV-2, that is often deleted on extended cell passage. [shared file(s): image.png] [2021-01-26 16:38:37] [Kristian Andersen] [thread - ID: 2021-01-26 16:38:37] Nice! Bob, can you please share the actual alignment? Would like to try and merge it with what I have. [2021-01-26 16:41:25] [Eddie Holmes] Great work Bob! Hoping to get the Yunnan bat virus sequences soon. [2021-01-26 17:20:24] [Kristian Andersen]