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1. 2021-01-23 17:13 Andrew Rambaut open
   Probably some of them (particularly those with multiple residues) are probably just plastic.
2. 2021-01-23 17:14 Andrew Rambaut open
   Will need to see how often some of these occur outside the background of B.1.1.7
3. 2021-01-23 17:15 Kristian G. Andersen open
   Yeah. Very interesting to see how several of these are shared with BRA/RSA variants though - I find that a little confusing
4. 2021-01-23 17:16 Kristian G. Andersen open
   I thought the mutations observed in P.1 / B.1.351 were likely fixed in a single individual and then took off in the population. But seeing them pop up here suggest to me that that likely wasn't the case. Maybe immune selection in_the population_, not _intrahost_, actually fixed them in the first place.
5. 2021-01-23 17:17 Kristian G. Andersen
   I think the UK lineage is likely a weird example of a chronic infection that took off, while the BRA/RSA lineages are just a result of selection on the population.
6. 2021-01-23 17:17 Andrew Rambaut open
   The plastic ones could have just been hitchhiking in the generating individual
7. 2021-01-23 17:17 Kristian G. Andersen open
   True
8. 2021-01-23 17:19 Andrew Rambaut open
   Trevor has been going around saying the RSA lineage arose in sequence based on some genomes with only some of the mutations but they are not old sequences and I have heard that Tulio uses some weird homebrew bioinformatics that may call for reference occasionally.
9. 2021-01-23 17:20 Kristian G. Andersen open
   Eh?

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