Chat message

Slack / Private Message Drop, p.416 [SLACK_000630] · slack_pm:msg:04305

Date: 2021-01-18 10:26
Type: chat message · slack
recipient: Robert F. Garry, Edward C. Holmes, Andrew Rambaut
speaker: Kristian G. Andersen

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It's bad indeed - very bad. To me it's not unexpected though - the RSA lineage has multiple mutations that had already been shown to affect immunity, so I can't say I'm surprised (this is unlike b117 - that one has less mutations that seem related to escape). It's much worse than I could have _hoped_ for though. Add to this that I'm getting increasingly concerned that this is because Eek leads to general immune escape and isn't just linked to changing asimple B cell epitope.

In context

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2021-01-18 09:56 Kristian G. Andersen open

Yeah, we'll have to wait and see - maybe SC2 only has a narrow window for escaping (some level of) immunity, but I'm not convinced that's the case - we only need to look to all the ccCoVs.I warned Alina about her "well adapted to human" comments, making it clear that compared to SARS, yes, that might look to be the case, but there's a whole world of viruses out there where what we're seeing (dN/dS) in SC2 isnothing special. We're definitely seeing that play out now.
2021-01-18 10:14 Kristian G. Andersen open

https://twitter.com/AdamJKucharski/status/1351228542143651840?s=20
2021-01-18 10:16 Kristian G. Andersen open

Starts ~40 mins: https://www.youtube.com/watch?v=Ja_tLG8CLAc
2021-01-18 10:17 Robert F. Garry open

That's worse than expected. Much worse.
2021-01-18 10:26 Kristian G. Andersen

It's bad indeed - very bad. To me it's not unexpected though - the RSA lineage has multiple mutations that had already been shown to affect immunity, so I can't say I'm surprised (this is unlike b117 - that one has less mutations that seem related to escape). It's much worse than I could have _hoped_ for though. Add to this that I'm getting increasingly concerned that this is because Eek leads to general immune escape and isn't just linked to changing asimple B cell epitope.
2021-01-18 10:30 Kristian G. Andersen open

I like this Salim guy though - very very good.
2021-01-18 10:39 Kristian G. Andersen open

Salim Abdool Karim - holy smokes, such a good scientific communicator. Probably the best I have seen during the entire pandemic - I feel like an idiot I didn't know about him before watching this presentation. https://en.wikipedia.org/wiki/Salim_Abdool_Karim
2021-01-18 10:42 Robert F. Garry open

Yes good - I chaired the study section that reviewed the last round of AIDS clinical trials groups grants a few months back. Karim and his wife clearly had the best application of the bunch. Not close.
2021-01-18 10:50 Kristian G. Andersen open

I'm impressed.

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