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Slack / Private Message Drop, p.372 [SLACK_000586] · slack_pm:msg:03873

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Immune escape plus enhanced fitness is ......worrisome.

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2021-01-09 10:12 Kristian G. Andersen open

We're talking orders of magnitude difference in binding affinity - that's not nothing....
2021-01-09 10:21 Robert F. Garry open

Looks like Eeek even though it doesn't seem to contact ACE2 nevertheless can enhance binding when coupled with Nelly. Surprising but perhaps not shocking.
2021-01-09 10:23 Kristian G. Andersen open

Yup - enhances it by quite a bit
2021-01-09 10:29 Robert F. Garry open

Poor preserved 2/3 predicted O-glycans just like Pooh.
2021-01-09 10:32 Robert F. Garry

Immune escape plus enhanced fitness is ......worrisome.
2021-01-09 10:32 Kristian G. Andersen open

That's to put it mildly...
2021-01-09 10:34 Kristian G. Andersen open

Also, this is basically the final confirmation that @Andrew Rambaut was absolutely correct in ringing the big redalarm bell:https://twitter.com/LindorffLarsen/status/1347916349704646656?s=20Looks like the doubling rate might be a little less in DK than UK, but clearly same trajectory.
2021-01-09 10:37 Kristian G. Andersen open

And I have mentioned this several times, but worth repeating - it's unclear to me we'll be able to control COVID inthe US in a couple of months. Just too much inaction and lack of coordination, coupled with pandemic fatigue. Iwould not be surprised if we reach 1m fatalities by summer.I hope I'm wrong. Very wrong.
2021-01-09 10:38 Robert F. Garry open

False reports of a new 'U.S. variant' originated from Dr. Deborah Birx on the task force.