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Slack / Private Message Drop, p.370 [SLACK_000584] · slack_pm:msg:03858

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Lot of immunosuppressed Africans, HIV and other causes, as well. So having the P681 changes may fit that meme.

In context

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2021-01-09 07:39 Robert F. Garry open

Interesting - P681R would make the FCS RRRAR right? which is predicted to be a much better site than PRRAR but not as good as RRAR/KR. Q613H is pretty analogous to the lion mutation (from my virological christmas card) Q613R, both to a positive charge at pH >6.
2021-01-09 07:42 Andrew Rambaut open

There are lions in Uganda.
2021-01-09 07:42 Andrew Rambaut open

(so I have heard - I was supposed to be going there last year, sigh)
2021-01-09 07:52 Robert F. Garry open

Ahhh yes - the Queen Victoria hotel is pretty special and you can take a side trip to the Ziika forest. Curious about Pooh, showing up in NIgeria (Christian Happi) and now Poor in Uganda. Not that many sequences from Africa, Something usual in Africans going on which I suspect relates to prior exposure to some yet uncharacterizedbetacornaviruses.
2021-01-09 07:54 Robert F. Garry

Lot of immunosuppressed Africans, HIV and other causes, as well. So having the P681 changes may fit that meme.
2021-01-09 08:00 Andrew Rambaut open

This is the new USA cluster with Eeek and Pooh: [shared file(s): image.png]
2021-01-09 08:11 Robert F. Garry open

All in Maryland? Worth keeping an eye on it for sure...
2021-01-09 08:12 Andrew Rambaut open

This one only has 484K but spans 4 months and 4 states: [shared file(s): image.png]
2021-01-09 08:14 Andrew Rambaut open

@Robert Garry Perhaps it was around the Capitol on Tuesday