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Slack / Private Message Drop, p.367 [SLACK_000581] · slack_pm:msg:03827

Date: 2021-01-07 17:05
Type: chat message · slack
mentioned: Andrew Rambaut
recipient: Robert F. Garry, Edward C. Holmes, Andrew Rambaut
speaker: Kristian G. Andersen
Topics: Furin cleavage site and molecular features

Recipients on this medium are inferred from channel membership, not per-message addressing.

@Andrew Rambaut "Does E484K induce a good immune response against E484 viruses or is Erik a total escape from the human repertoire[s]? I doubt it, but who knows". I was wondering about this very same question yesterday... I assume an updated spike protein should likely do it, but as you say, who knows (if it's not, I'm going toshoot myself).

Extracted statements

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Statement	Grade	Attribution	Stance
I assume an updated spike protein should likely do it, but as you say, who knows (if it's not, I'm going toshoot myself).	needs context	uncertain explicit hedge	asserts

Statement

Grade

Attribution

Stance

I assume an updated spike protein should likely do it, but as you say, who knows (if it's not, I'm going toshoot myself).

needs context

uncertain explicit hedge

asserts

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2021-01-07 15:51 Edward C. Holmes open

@Andrew Rambaut Evolution is a pain in the arse.
2021-01-07 16:16 Robert F. Garry open

@Andrew Rambaut Yeah - truly. At this point it's literally a guess as to what to change the spike to in v2.0 vaccines. Does E484K induce a good immune response against E484 viruses or is Erik a total escape from the humanrepertoire[s]? I doubt it, but who knows. Need to get some plasma from people that have been infected with the UKand ZA variants to see if they actually recognize the putative epitopes are not.
2021-01-07 16:29 Andrew Rambaut open

@Andrew Rambaut Plenty of that plasma around at the moment in the UK
2021-01-07 17:05 Kristian G. Andersen

@Andrew Rambaut "Does E484K induce a good immune response against E484 viruses or is Erik a total escape from the human repertoire[s]? I doubt it, but who knows". I was wondering about this very same question yesterday... I assume an updated spike protein should likely do it, but as you say, who knows (if it's not, I'm going toshoot myself).

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